Forkhead Box Transcription Factors: Double-Edged Swords in Cancer.
Forkhead Box Transcription Factors: Double-Edged Swords in Cancer.
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叉头盒转录因子：癌症中的双刃剑。
DOI：
10.1158/0008-5472.can-21-3371
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发表时间：
2022-06-06
期刊：
影响因子：
11.2
通讯作者：
Mani SA
中科院分区：
文献类型：
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作者：
Castaneda M;Hollander PD;Mani SA
癌症疗法存在过多的治疗选择，但许多都受到副作用和内在或获得性耐药性的限制。对更有效的靶向癌症治疗的需求导致了对叉头框（FOX）转录因子作为可能的药物靶点的关注。FOXA 1和FOXM 1等叉头因子通过调节上皮-间充质转化参与激素调节、免疫系统调节和疾病进展。叉头因子可以影响癌症的发展、进展、转移和耐药性。在这篇综述中，我们讨论了叉头因子在支持癌症的生物过程中的各种作用，以及它们作为先锋因子的功能和它们作为靶向转录因子在抗癌斗争中的潜力。
A plethora of treatment options exist for cancer therapeutics, but many are limited by side effects and either intrinsic or acquired resistance. The need for more effective targeted cancer treatment has led to the focus on forkhead box (FOX) transcription factors as possible drug targets. Forkhead factors such as FOXA1 and FOXM1 are involved in hormone regulation, immune system modulation, and disease progression through their regulation of the epithelial–mesenchymal transition. Forkhead factors can influence cancer development, progression, metastasis, and drug resistance. In this review, we discuss the various roles of forkhead factors in biological processes that support cancer as well as their function as pioneering factors and their potential as targetable transcription factors in the fight against cancer.
DOI：
10.4161/cc.8.10.8408
发表时间：
2009-05-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
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作者：
Jung-Hynes B;Ahmad N
通讯作者：
Ahmad N