Synthesis and antiviral activities of synthetic glutarimide derivatives.
Synthesis and antiviral activities of synthetic glutarimide derivatives.
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DOI：
10.1248/cpb.58.1436
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发表时间：
2010-11
影响因子：
1.7
通讯作者：
Xingyue Ji;Z. Zhong;Si-tu Xue;Shuai Meng;Wei-ying He;Rongmei Gao;Yu-huan Li;Zhuo-rong Li
中科院分区：
文献类型：
--
作者：
Xingyue Ji;Z. Zhong;Si-tu Xue;Shuai Meng;Wei-ying He;Rongmei Gao;Yu-huan Li;Zhuo-rong Li
合成了一系列新的戊二酰亚胺化合物，并对其抗病毒活性进行了评价。抗柯萨奇病毒B3 （Cox B3）活性最强的化合物为5、6f、7e和9，抗流感病毒A（流感A）的化合物为10和6f，抗单纯疱疹病毒2 （HSV-2）的化合物为7a。然而，大多数合成的戊二酰亚胺对甲型流感、Cox B3和HSV-2的活性明显弱于天然的戊二酰亚胺化合物。基于结果，β-取代部分的共轭系统似乎提供了更强的抗病毒活性。
A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.