Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat.
Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat.
复制标题
先天性无助大鼠室旁下丘脑代谢亢进。
DOI：
10.1016/s0304-3940(01)02142-5
复制
发表时间：
2001
影响因子：
2.5
通讯作者：
Gonzalez-Lima,F
中科院分区：
文献类型：
--
作者：
Shumake,J;Edwards,E;Gonzalez-Lima,F
这只先天无助的老鼠被选择性地培育成抑郁症的行为特征模型，它在额叶和扣带回皮质中显示出的代谢活动模式与人类抑郁和悲伤成像研究中检测到的相似。本研究将相同的代谢映射技术（定量细胞色素氧化酶组织化学）扩展到下丘脑，在6个核团中评估活动水平：室旁核、内侧视前区、外侧下丘脑区、视上核、视交叉上核和腹内侧核。无助的老鼠与一种非无助的老鼠进行了比较，这些老鼠是为了抵抗压力而选择性饲养的。只有室旁核表现出显着的组间差异，与无助的大鼠表现出代谢升高和非无助的大鼠表现出相对于正常大鼠的代谢降低。因此，室旁核的活动可能与无助行为的遗传易感性有关。
The congenitally helpless rat, selectively bred to model behavioral features of depression, has shown metabolic activity patterns in frontal and cingulate cortex similar to those detected in human imaging studies of depression and sadness. This study extends the same metabolic mapping technique (quantitative cytochrome oxidase histochemistry) to the hypothalamus, where activity levels were assessed in six nuclei: paraventricular nucleus, medial preoptic area, lateral hypothalamic area, supraoptic nucleus, suprachiasmatic nucleus, and ventromedial nucleus. Helpless rats were compared with a strain of non-helpless rats selectively bred for stress resistance. Only the paraventricular nucleus showed a significant group difference, with helpless rats showing elevated metabolism and non-helpless rats showing reduced metabolism relative to normal rats. Thus, paraventricular nucleus activity may be associated with genetic susceptibility to helpless behavior.