Tumor‐associated antigen, TA‐4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix. Serial Determinations and Tissue Localization
Tumor‐associated antigen, TA‐4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix. Serial Determinations and Tissue Localization
复制标题
肿瘤相关抗原 TA-4，用于监测宫颈鳞状细胞癌的治疗效果。连续测定和组织定位。
作者：
T. Maruo;K. Shibata;A. Kimura;M. Hoshina;M. Mochizuki
用放射免疫法和免疫过氧化物酶技术检测了宫颈鳞癌患者血清和肿瘤组织中肿瘤相关抗原(TA-4)的水平。以2.5 ng/ml的血清为任意限值，在5.5%的健康对照和53.6%的宫颈鳞癌患者中观察到阳性结果。血清TA-4升高的均值和发生率随着疾病分期的推进而显著升高。然而，在疾病的早期阶段，血清TA-4没有显著增加。血清中升高的TA-4在根治性手术后72小时内迅速降至正常，但如果不能进行完全切除，则仍保持升高。在放射治疗的情况下，血清和肿瘤组织中的TA-4水平在最初的2000拉德照射期间经常升高，随后在总共超过4000拉德的照射后下降。在放射治疗过程中观察到的血清TA-4下降到正常水平与宫颈组织病理标本中活癌细胞的消失密切相关。免疫组织化学TA-4在大细胞非角化性癌中表达，而在小细胞非角化性癌中不表达。这些结果表明，宫颈鳞癌组织中TA-4抗原的表达与肿瘤细胞分化程度有关，血清TA-4检测虽然对宫颈鳞癌的早期诊断有一定的局限性，但仍可作为监测宫颈鳞癌个体化治疗效果的一种手段。
The level of tumor‐associated antigen (TA‐4) was determined in the serum and tumor tissue of patients with squamous cell carcinoma of the cervix by radioimmunoassay and immunoperoxidase techniques. Using an arbitrary limit of 2.5 ng/ml of serum, positive values were observed in 5.5% of healthy controls and 53.6% of patients with cervical squamous carcinoma. The mean value and incidence of elevation of serum TA‐4 increased significantly with advancing disease stage. There was, however, no significant increase in serum TA‐4 in the early stages of disease. Elevated TA‐4 in serum rapidly fell to normal within 72 hours after radical surgery, but remained elevated if complete excision could not be performed. In case of radiotherapy, TA‐4 levels in serum and tumor tissue often increased during the administration of the initial 2000 rad, and subsequently declined after the administration of a total of more than 4000 rad. The decline of serum TA‐4 to normal observed during radiotherapy was found to be closely correlated with the disappearance of viable cancer cells in histopathologic specimens from the cervix. Immunohistochemical TA‐4 staining was present in large cell nonkeratinizing carcinoma, but not in small cell nonkeratinizing carcinoma. These results indicate that the expression of TA‐4 antigen in cervical squamous carcinoma is related to differentiation of the tumor cells and that serum TA‐4 determination, despite its limitation for early diagnosis, provides a potential means for monitoring the effects of individual therapy for cervical squamous cell carcinoma.