NASAL DELIVERY OF [C-14] DEXTROMETHORPHAN HYDROCHLORIDE IN RATS - LEVELS IN PLASMA AND BRAIN
NASAL DELIVERY OF [C-14] DEXTROMETHORPHAN HYDROCHLORIDE IN RATS - LEVELS IN PLASMA AND BRAIN
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DOI：
10.1002/jps.2600810806
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发表时间：
1992-08-01
影响因子：
3.8
通讯作者：
BEHL, CR
中科院分区：
文献类型：
--
作者：
CHAR, H;KUMAR, S;BEHL, CR
右美沙芬（DM）是一种神经保护剂。其作用机制被认为是通过n -甲基- d -天冬氨酸受体阻断。大脑中DM的浓度被认为是剂量和途径依赖的。通过鼻腔给药最近受到了很多关注，因为从这种途径的药物吸收跟随静脉注射，没有第一过效应。与静脉给药相比，经鼻给药的DM在脑部的吸收量为65.9%，而经鼻给药的血浆生物利用度为78.8%。鼻途径是一种可行的替代肠外途径给药DM。
Dextromethorphan (DM) is a neuroprotective agent. The mechanism of action is believed to be by N-methyl-D-aspartate receptor blockade. The concentration of DM in the brain is believed to be dose and route dependent. Delivery by the nasal route has received a lot of attention recently, because drug absorption from this route follows intravenous profiles with no first-pass effect. The uptake of DM in the brain from the nasal route was 65.9% compared with the intravenous route, whereas the plasma bioavailability from the nasal route was 78.8%. The nasal route is a viable alternative to the parenteral route for DM administration.