ERP ABNORMALITIES DURING SEMANTIC PROCESSING IN SCHIZOPHRENIA
ERP ABNORMALITIES DURING SEMANTIC PROCESSING IN SCHIZOPHRENIA
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DOI：
10.1016/0920-9964(93)90059-r
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发表时间：
1993-10-01
影响因子：
4.5
通讯作者：
MCCARLEY, RW
中科院分区：
文献类型：
--
作者：
ADAMS, J;FAUX, SF;MCCARLEY, RW
为了研究精神分裂症患者思维障碍的神经生理和认知特征，我们检测了由语义不一致的单词和短语引发的特定事件相关脑电位（N400）的振幅、潜伏期和地形。12名慢性精神分裂症患者和12名年龄匹配的对照组受试者阅读视觉呈现的句子，这些句子要么语义正确（例如，“人们在当地教堂祈祷”），要么结尾错误（例如，“每个星期天早上，人们在他们当地的巢穴祈祷”）。与正常对照相比，精神分裂症患者的N400振幅显著降低，语义异常末梢潜伏期增加。此外，N400后的晚期阳性成分在精神分裂症患者中振幅显著降低。然而，在28个电极位置检测的N400及其晚期正电位的地形分布方面，患者和对照组没有显着差异。因此，精神分裂症患者的N400地形不伴有不对称性，而这种不对称性通常是精神分裂症患者听觉P300障碍的特征。我们的结论是，这些发现可能反映了慢性精神分裂症患者注意力过程的深刻障碍。
To examine the neurophysiological and cognitive characteristics of thought disturbance in schizophrenic patients, we examined the amplitude, latency, and topography of a specific event-related brain potential (ERP), the N400, which is elicited by semantically incongruent words and phrases. Twelve chronic schizophrenic patients and twelve age-matched control subjects read sentences presented visually that had either semantically correct (e.g., 'People pray in their local church') or incorrect endings (e.g., 'Every Sunday morning people pray in their local nest'). Relative to normal controls, schizophrenic patients had significantly reduced N400 amplitude and increased latency to semantically anomalous endings. Additionally, a late positive component which follows the N400 was significantly reduced in amplitude in schizophrenic patients. However, patients and controls did not differ significantly in terms of the topographical distribution of either the N400 or its late positive potential, examined at 28 electrode sites. Thus, N400 topography in schizophrenic patients was not accompanied by the asymmetry which frequently characterizes the well known auditory P300 disturbance in schizophrenic patients. We concluded that these findings may reflect a profound disturbance in attentional processes in chronic schizophrenia.