Estimating primary care attendance rates for fever in infants after meningococcal B vaccination in England using national syndromic surveillance data
Estimating primary care attendance rates for fever in infants after meningococcal B vaccination in England using national syndromic surveillance data
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DOI：
10.1016/j.vaccine.2017.11.076
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发表时间：
2018-01-25
期刊：
影响因子：
5.5
通讯作者：
Elliot, Alex J.
中科院分区：
文献类型：
--
作者：
Harcourt, Sally;Morbey, Roger A.;Elliot, Alex J.
背景资料：2015年9月，英国成为第一个将多组分B群脑膜炎球菌疫苗（4 CMen B）引入国家婴儿免疫规划的国家。在早期的临床试验中，当4CMenB与其他常规疫苗一起接种时，51-61%的婴儿出现发烧。虽然建议使用预防性扑热息痛，但多达3%的父母可能会在接种疫苗后因发热而就医。我们使用了研究水平的全科医生咨询，以确定任何增加的出勤率为疫苗合格的婴儿以下4CMenB介绍在England.Methods：咨询婴儿全因发热疫苗引进后的一年中确定从凤凰合作伙伴关系（TPP）ResearchOne全科医学数据库使用读取（CTV 3）代码。计算符合接种条件的年龄组的平均每日咨询率和发病率比（IRR），并与疫苗引入前两年进行比较。结果：符合接种条件的7-10周龄奥尔兹的全因发热咨询是接种疫苗前和接种疫苗后的1.6倍（IRR，1.58; 95% CI，1.22-2.05），15-18周龄的婴儿高1.5倍（IRR 1.47; 95% CI，1.17-1.86）。0-6周龄和11-14周龄之间无显著差异。应用疫苗接种前和接种后的咨询率之间的差异，4CMenB疫苗合格的年龄组在英格兰估计1825额外的发热咨询后的一年4CMenB introduction.Conclusions：我们发现一个小的，但显着的差异，在所有原因的发热咨询率在疫苗合格的婴儿谁会收到4CMenB与其他疫苗。皇冠版权所有（C）2017由爱思唯尔有限公司发布。保留所有权利。
Background: In September 2015, the United Kingdom became the first country to introduce the multi component group B meningococcal vaccine (4CMenB) into a national infant immunisation programme. In early clinical trials 51-61% of infants developed a fever when 4CMenB was administered with other routine vaccines. Whilst administration of prophylactic paracetamol is advised, up to 3% of parents may seek medical advice for fever following vaccination. We used research-level general practitioner consultations to identify any increase in attendances for all-cause fever in vaccine-eligible infants following 4CMenB introduction in England.Methods: Consultations for infant all-cause fever in the year following the vaccine introduction were identified from The Phoenix Partnership (TPP) ResearchOne general practice database using Read (CTV3) codes. Average daily consultation rates and incidence rate ratios (IRRs) were calculated for vaccine-eligible age groups and compared to the two years preceding vaccine introduction. The difference between pre- and post-vaccine all-cause fever consultations was estimated.Results: All-cause fever consultations in vaccine-eligible 7-10 week olds were 1.6-fold higher (IRR, 1.58; 95% CI, 1.22-2.05) compared to the two previous years and 1.5-fold higher (IRR 1.47; 95% CI, 1.17-1.86) in 15-18 week-olds. There were no significant differences in 0-6 or 11-14 week-olds. Applying the difference between pre- and post-vaccine consultation rates to the 4CMenB vaccine-eligible age groups across England estimated 1825 additional fever consultations in the year following 4CMenB introduction.Conclusions: We found a small but significant difference in all-cause fever consultation rates in vaccine eligible infants who would have received 4CMenB with other vaccines. Crown Copyright (C) 2017 Published by Elsevier Ltd. All rights reserved.