Alcohol aversion generalization in rats: specific disruption of taste and odor cues with gustatory neocortex or olfactory bulb ablations.
Alcohol aversion generalization in rats: specific disruption of taste and odor cues with gustatory neocortex or olfactory bulb ablations.
复制标题
大鼠的酒精厌恶泛化：味觉新皮质或嗅球消融对味觉和气味线索的特异性破坏。
DOI：
10.1037//0735-7044.102.5.733
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发表时间：
1988
影响因子：
1.9
通讯作者：
Metzler,CW
中科院分区：
文献类型：
--
作者：
Kiefer,SW;Morrow,NS;Metzler,CW
将切除味觉新皮层（实验1）和切除嗅球（实验2）的大鼠与正常大鼠在酒精厌恶训练后对单一味觉溶液（蔗糖、氯化钠、盐酸奎宁、盐酸）和复合味觉溶液（四种单一味觉剂成对）的厌恶概括进行比较。所有大鼠获得平等和强烈的酒精厌恶。对照组大鼠表现出一致的厌恶泛化的蔗糖加奎宁和蔗糖加盐酸的解决方案，没有显着的泛化发生的单一味剂，除了一个弱的泛化蔗糖在实验2。味觉新皮层消融大鼠未能表现出厌恶泛化的任何味道的解决方案。大鼠嗅球切除显示相同的厌恶泛化功能的控制大鼠，但表现出显着更快的消退酒精厌恶比训练的控制大鼠。从本实验的结果表明，在酒精厌恶学习，大鼠缺乏味觉新皮层使用气味线索（没有味道概括），而大鼠缺乏嗅球利用味觉线索（正常的味道概括）。（PsycINFO数据库记录（c）2019阿帕，保留所有权利）
Rats with ablations of the gustatory neocortex (Experiment 1) and rats with olfactory bulb ablations (Experiment 2) were compared with normal rats for aversion generalization to both single taste solutions (sucrose, sodium chloride, quinine hydrochloride, hydrochloric acid) and compound taste solutions (pairs of the four single tastants) following alcohol aversion training. All rats acquired equal and strong alcohol aversions. Control rats showed consistent aversion generalization to both the sucrose plus quinine and the sucrose plus hydrochloric acid solutions; no significant generalization occurred to the single tastants except a weak generalization to sucrose in Experiment 2. Rats with gustatory neocortical ablations failed to show aversion generalization to any of the taste solutions. Rats with olfactory bulbectomies displayed the same aversion generalization functions as control rats but exhibited significantly faster extinction of the alcohol aversion than did the trained control rats. Results from the present experiments suggest that during alcohol aversion learning, rats lacking gustatory neocortex use odor cues (no taste generalization), whereas rats lacking olfactory bulbs utilize taste cues (normal taste generalization).(PsycINFO Database Record (c) 2019 APA, all rights reserved)