Silicon-29 nuclear magnetic resonance spectroscopy detection limits.
Silicon-29 nuclear magnetic resonance spectroscopy detection limits.
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Silicon-29核磁共振波谱检测限。
DOI：
10.1021/ac980547k
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发表时间：
1999
影响因子：
7.4
通讯作者：
Kinrade,SD
中科院分区：
文献类型：
--
作者：
Knight,CT;Kinrade,SD
我们证明了未经修改的商用高场（17.61T）核磁共振波谱仪使用DEPT脉冲序列能够检测到每个自旋位点浓度低至150 ng/mL （150 ppb）的含硅物质。这是在硅胶乳房植入物受体血液中硅浓度的范围内，由ICP分析确定，并表明，与文献中表达的观点相反，理论上，硅核磁共振可能足够敏感，可用于确定存在的含硅物种的性质。综述了影响核磁共振光谱检测限的因素。
We show that an unmodified, commercially available high-field (17.61T) NMR spectrometer using the DEPT pulse sequence is capable of detecting silicon-containing species down to concentrations of 150 ng/mL (150 ppb) per spin site. This is in the range given for the concentration of silicon in the blood of silicone breast implant recipients, as determined by ICP analysis, and demonstrates that, contrary to the view expressed in the literature, in theory29Si NMR may be sufficiently sensitive to be of use in determining the nature of the silicon-containing species present. A summary of the factors affecting the detection limits in NMR spectroscopy is given.