Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200
Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200
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DOI：
10.4049/jimmunol.175.7.4441
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发表时间：
2005-10-01
影响因子：
4.4
通讯作者：
Arase, H
中科院分区：
文献类型：
--
作者：
Shiratori, I;Yamaguchi, M;Arase, H
人和啮齿类动物的CD 200都是由抑制性CD 200 R识别的，这些分子在免疫系统的调节中起着重要的作用。几种病毒，如人类疱疹病毒-6（HHV-6）、HHV-7和HHV-8，具有CD 200同源物，表明这些病毒通过CD 200 R调节免疫应答。在这项研究中，我们分析了人CD 200和病毒CD 200同源物对人CD 200受体表达细胞的影响。我们发现人CD 200 R主要在嗜碱性粒细胞上表达，其表达量高于其他人外周血白细胞。此外，病毒CD 200同源物以及人CD 200被人CD 200 R识别，并且这些CD 200蛋白下调嗜碱性粒细胞的活化。这些结果表明，CD 200 R是嗜碱性粒细胞活化的重要调节分子。此外，几种病毒上存在CD 200同源物表明嗜碱性粒细胞功能与病毒感染之间存在潜在的独特关系。
Human and rodent CD200 are recognized by the inhibitory CD200R, and these molecules play an important role in the regulation of the immune system. Several viruses, such as human herpesvirus-6 (HHV-6), HHV-7, and HHV-8, possess a CD200 homologue, suggesting that these viruses regulate the immune response via CD200R. In this study, we analyzed the effect of human CD200 and the viral CD200 homologues on human CD200R-expressing cells. We found that human CD200R is predominantly expressed on basophils in amounts higher than on other human peripheral blood leukocytes. Furthermore, the viral CD200 homologues as well as human CD200 were recognized by human CD200R, and the activation of basophils was down-regulated by these CD200 proteins. These results suggested that CD200R is an important regulatory molecule of basophil activation. In addition, the presence of CD200 homologues on several viruses suggests a potentially unique relationship between basophil function and viral infection.