The paraoxonase polymorphism in a Saudi Arabian population.
The paraoxonase polymorphism in a Saudi Arabian population.
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沙特阿拉伯人群中的对氧磷酶多态性。
DOI：
10.1097/00008571-199306000-00004
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
LaDu,BN
中科院分区：
文献类型：
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作者：
Nogueira,CP;Evans,DA;LaDu,BN
对氧磷酶的多态性进行了分析，从沙特阿拉伯的248个人的血清。使用的表型分析方法是基于对氧磷酶/芳基酯酶的比例，在早期的研究中描述。该比率在样品中的分布是三峰的，并且它为鉴定三种表型提供了良好的分辨率：A-低活性纯合子; B-高活性纯合子; AB-相应的杂合子，具有中间活性。低活性等位基因A的基因频率为0.7296，高活性等位基因B的基因频率为0.2704。这些频率接近于在北美和欧洲的高加索人样本中观察到的频率。样本中的表型频率符合Hardy-Weinberg平衡。
The paraoxonase polymorphism was analysed in the serum of 248 individuals from Saudi Arabia. The phenotyping method used was one based on the ratio of paraoxonase/arylesterase, described in earlier studies. The distribution of this ratio in the sample was trimodal and it provided a good resolution for the identification of three phenotypes: A–homozygotes with low activity; B–homozygotes with high activity; AB–the corresponding heterozygotes, with intermediate activity. Gene frequencies were 0.7296 for the allele A with low activity and 0.2704 for the allele B with high activity. These frequencies are close to those observed in Caucasian samples from North America and Europe. Phenotypic frequencies in the sample fit the Hardy-Weinberg equilibrium.