Implantable CMOS neuro-stimulus chip for visual prosthesis
Implantable CMOS neuro-stimulus chip for visual prosthesis
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DOI：
10.1007/s11432-010-4175-6
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发表时间：
2011-02
期刊：
影响因子：
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通讯作者：
Xu Zhang;Weihua Pei;Beiju Huang;Shujing Wang;Ning Guan;Kai Guo;Yu Wang;Q. Gui;Jin Chen;Kai Wang;Huijuan Wu;Xiaoxin Li;Kai Li;Hongda Chen
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文献类型：
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作者：
Xu Zhang;Weihua Pei;Beiju Huang;Shujing Wang;Ning Guan;Kai Guo;Yu Wang;Q. Gui;Jin Chen;Kai Wang;Huijuan Wu;Xiaoxin Li;Kai Li;Hongda Chen
本文介绍了一种2×2像素的原型芯片，用于植入外部视网膜变性失明患者体内。这种视觉假体芯片模仿退化的感光细胞，感知入射光并刺激视网膜或视神经的剩余健康层。每个像素集成了光电二极管和刺激脉冲发生器，将眼睛上的照明转换为3位分辨率的双相电流脉冲。片上电荷消除模块用于对每个电极部位放电，以确保组织安全。该芯片采用0.18 μm N阱CMOS（complementary metal oxide semiconductor）1 P6 M Mix-signal工艺设计和制作，采用± 2.5V双电压供电。在麻醉的兔子上证明了所制造的芯片的功能。神经刺激芯片通过板上触发接口和柔性电极成功地诱发了视觉皮层的神经反应。
A prototype chip with 2×2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this paper. This visual prosthesis chip imitates the degenerated photoreceptor cells, senses the incident light and stimulates the remaining healthy layers of retina or optic nerve. Each pixel integrates photodiode and stimulus pulse generator, converting the illumination on the eyes into 3-bit resolution bi-phasic current pulses. On-chip charge cancellation modules are used to discharge each electrode site for tissue safety. The prototype chip is designed and fabricated in 0.18-μm N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process, with a ±2.5 V dual voltage supply. The functionality of the fabricated chip is demonstrated on anesthetized rabbits. Neural responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.