Functional consequences following methamphetamine-induced neuronal damage.
Functional consequences following methamphetamine-induced neuronal damage.
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甲基苯丙胺引起的神经元损伤后的功能后果。
DOI：
10.1007/bf00439543
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发表时间：
1989
影响因子：
3.4
通讯作者：
Wagner,GC
中科院分区：
文献类型：
--
作者：
DeVito,MJ;Wagner,GC
在几种已知影响损伤程度的不同条件下，评估了甲基苯丙胺诱导的神经元损伤后的功能后果。结果发现，甲基苯丙胺(6.25 mg/kg SC，间隔2小时四次给药)导致纹状体多巴胺和5-羟色胺的长期耗竭，而抗氧化剂抗坏血酸(100 mg/kg)可减轻这些耗竭，而超氧化物歧化酶抑制剂二乙基二硫代氨基甲酸酯(200 mg/kg)则加剧这些耗竭。在这些不同条件下反复服用甲基苯丙胺所导致的多巴胺消耗，并不会导致基线条件下甜炼乳溶液的消费量发生任何变化。然而，当这些受损的动物被急性注射甲基苯丙胺激发时，观察到对这种化合物减少乳汁摄入量的影响有一种改变的敏感性。也就是说，急性服用甲基苯丙胺减少甜炼乳摄入量的程度与甲基苯丙胺引起的多巴胺和5-羟色胺消耗的程度高度相关。这些观察结果支持甲基苯丙胺诱导的神经元损伤是由自由基形成介导的假设，并表明行为测量可能被用来评估神经元损伤。
The functional consequences following methamphetamine-induced neuronal damage were evaluated under several different conditions known to affect the magnitude of the lesion. It was found that methamphetamine (6.25 mg/kg administered SC, four times at 2-h intervals) caused long-lasting depletions of striatal dopamine and serotonin and that pretreatment with the antioxidant, ascorbic acid (100 mg/kg), attenuated these depletions, whereas pretreatment with the superoxide dismutase inhibitor diethyldithiocarbamate (200 mg/kg) exacerbated these depletions. The dopamine depletions resulting from the repeated administration of methamphetamine under these various conditions did not result in any alteration in the consumption of a sweetened-condensed milk solution under baseline conditions. However, when these lesioned animals were challenged with acutely administered methamphetamine, it was observed that there was an altered sensitivity to the milk intake decreasing effects of this compound. That is, the degree to which the acutely administered methamphetamine reduced the intake of sweetened-condensed milk was highly correlated with the magnitude of the methamphetamine-induced dopamine and serotonin depletions. These observations support the hypothesis that methamphetamine-induced neuronal damage is mediated by free radical formation and indicate that behavioral measures may be employed to assess neuronal damage.