A new class of mesomorphic copolymers: Copolymers with a saccharide block and a peptide block
A new class of mesomorphic copolymers: Copolymers with a saccharide block and a peptide block
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DOI：
10.1002/macp.1977.021780530
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发表时间：
1977-05
影响因子：
2.5
通讯作者：
A. Douy;B. Gallot
中科院分区：
文献类型：
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作者：
A. Douy;B. Gallot
最近，我们报道了具有疏水聚乙烯嵌段和亲水多肽嵌段的嵌段共聚物的合成和结构的研究。这种共聚物可以被认为是两性蛋白的简化模型。在膜蛋白中，糖蛋白是特别感兴趣的：它们是多种病毒、凝集素和特异性抗体的受体3 '，并且涉及细胞识别和细胞接触抑制3'。因此，获得应该能够模拟糖蛋白行为的共聚物是非常有吸引力的。为此，我们进行了合成和研究的嵌段共聚物与亲水性糖嵌段和疏水性肽嵌段。本文简要地综述了两亲性嵌段共聚物0”-Eb和Ofl-Eb的合成和结构研究，其中亲水性糖嵌段是糖蛋白（卵类粘蛋白）的碳水化合物部分（0“或0”），疏水性嵌段是聚（对苄基-L-谷氨酸）嵌段（Eb）。
Recently we have reported the synthesis and the study of the structure of block copolymers with a hydrophobic polyvinyl block and a hydrophilic polypeptide block”. Such copolymers may be considered as simplified models of amphipatic proteins”. Among membrane proteins, glycoproteins are of particular interest: they are receptors for a variety of viruses, lectins, and specific antibodies3’and are implicated in cell recognition and cell contact inhibition3’. Thus, it is very attractive to obtain copolymers which should be able to simulate the behaviour of glycoproteins. For that purpose we have undertaken the synthesis and the study of block copolymers with a hydrophilic saccharide block and a hydrophobic peptide block. In this paper, we shall briefly sum up the synthesis and the study of the structure of amphipatic block copolymers 0”-Eb and Ofl-Eb where the hydrophilic saccharide block is a carbohydrate fraction (0 “or 0”) of a glycoprotein (ovomucoid) and the hydrophobic block is a poly (p-benzyl-L-glutamate) block (Eb).