Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study
Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study
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DOI：
10.1177/0891988704269819
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发表时间：
2004-12-01
影响因子：
2.6
通讯作者：
Potter, GG
中科院分区：
文献类型：
--
作者：
Steffens, DC;Welsh-Bohmer, KA;Potter, GG
本文提出了一种方法，用于跟踪一组老年抑郁症患者，以检查抑郁症的神经认知结果。共有265名抑郁症患者和138名60岁及以上的健康、非抑郁症对照者完成了至少1年的随访数据，由老年精神病学家定期进行临床评估。141名患者和137名对照组进行了神经心理测试。一个由专家组成的共识小组审查了63名疑似认知障碍的抑郁症受试者。抑郁组中的27人被诊断为痴呆，其中11人患有阿尔茨海默病，8人患有血管性痴呆，8人患有病因不明的痴呆。此外，25人有其他形式的认知障碍，11人被认为是认知正常的。在老年对照组中，2人出现严重的认知障碍，临床诊断为痴呆。在抑郁组中，这个年龄段的痴呆症发病率比预期的要高得多。这些结果与先前有关抑郁症和后期痴呆的证据一致。未来的研究需要检查抑郁症患者神经认知能力下降的神经影像学、遗传、临床和社会预测因素。
A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of follow-up data underwent periodic clinical evaluation by a geriatric psychiatrist. A subset of 141 patients and 137 controls had neuropsychological testing. A consensus panel of experts reviewed 63 depressed subjects with suspected cognitive impairment. Twenty-Seven individuals in the depressed group were assigned diagnoses of dementia, including 11 with Alzheimer's disease, 8 with vascular dementia, and 8 with dementia of undetermined etiology. In addition, 25 individuals had other forms of cognitive impairment, and 11 were considered cognitively normal. Among elderly controls, 2 developed substantial cognitive impairment with clinical diagnoses of dementia. Among the depressed group, the incidence rates for dementia for this age are much higher than would be expected. These results are consistent with prior evidence linking depression and later dementia. Future studies are needed to examine neuroimaging and genetic, clinical, and social predictors of neurocognitive decline in depression.