The Hippo Signaling Network and Its Biological Functions.
The Hippo Signaling Network and Its Biological Functions.
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DOI：
10.1146/annurev-genet-120417-031621
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发表时间：
2018-11-23
影响因子：
11.1
通讯作者：
Irvine KD
中科院分区：
文献类型：
--
作者：
Misra JR;Irvine KD
Hippo信号转导是一个进化上保守的网络，在调节细胞增殖和细胞命运以控制器官生长和再生中发挥核心作用。它促进LATS激酶的激活，LATS激酶通过抑制哺乳动物中转录共激活蛋白雅普和TAZ或果蝇中Yorkie的活性来控制基因表达。包括生物化学和生物力学线索在内的多种上游输入调节Hippo信号传导，这使其能够作为细胞物理环境的传感器和生长控制信号的整合者发挥关键作用。该途径的几个组分定位于细胞-细胞连接处，并通过细胞极性、细胞接触和细胞骨架对Hippo信号传导进行调节。Hippo信号转导的下调促进不受控制的细胞增殖并损害分化，并且与癌症相关。我们回顾了目前对Hippo信号传导的理解，强调了阐明其调控机制和生物学功能的进展。
Hippo signaling is an evolutionarily conserved network that plays a central role in regulating cell proliferation and cell fate to control organ growth and regeneration. It promotes activation of the LATS kinases, which control gene expression by inhibiting the activity of the transcriptional co-activator proteins YAP and TAZ in mammals, or Yorkie in Drosophila. Diverse upstream inputs including both biochemical and biomechanical cues regulate Hippo signaling, which enable it to play a key role as a sensor of cells’ physical environment and an integrator of growth control signals. Several components of this pathway localize to cell-cell junctions, and contribute to regulation of Hippo signaling by cell polarity, cell contacts, and the cytoskeleton. Down-regulation of Hippo signaling promotes uncontrolled cell proliferation and impairs differentiation, and is associated with cancer. We review current understanding of Hippo signaling, highlighting progress in elucidating its regulatory mechanisms and biological functions.
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影响因子：
21.3
作者：
Cox AG;Hwang KL;Brown KK;Evason K;Beltz S;Tsomides A;O'Connor K;Galli GG;Yimlamai D;Chhangawala S;Yuan M;Lien EC;Wucherpfennig J;Nissim S;Minami A;Cohen DE;Camargo FD;Asara JM;Houvras Y;Stainier DYR;Goessling W
通讯作者：
Goessling W
影响因子：
9.2
作者：
Codelia, Veronica A.;Sun, Gongping;Irvine, Kenneth D.
通讯作者：
Irvine, Kenneth D.
影响因子：
4.8
作者：
Chan, Siew Wee;Lim, Chun Jye;Hong, Wanjin
通讯作者：
Hong, Wanjin
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
11.8
作者：
Baumgartner, Roland;Poernbacher, Ingrid;Stocker, Hugo
通讯作者：
Stocker, Hugo