Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population
Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population
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DOI：
10.1111/j.1744-313x.2009.00848.x
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发表时间：
2009-08
影响因子：
2.2
通讯作者：
M. L. Wang;J. Lai;Y. Zhu;H. B. Zhang;C. Li;J. Wang;Y. Li;A. G. Yang;B. Jin
中科院分区：
文献类型：
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作者：
M. L. Wang;J. Lai;Y. Zhu;H. B. Zhang;C. Li;J. Wang;Y. Li;A. G. Yang;B. Jin
我们报告，与对照组相比，肾综合征出血热 (HFRS) 患者中 HLA-DRB1*09（51% vs. 23%，P = 0.002，OR = 3.57）和 HLA-B*46-DRB1*09（26% vs. 8%，P = 0.018，OR = 3.76）的发生率显着高于对照组，这表明汉坦病毒诱发高频RS 与中国汉族人群的遗传倾向有关。
We report a significantly higher occurrence of HLA‐DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA‐B*46‐DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus‐induced HFRS is associated with a genetic predisposition in the Chinese Han population.