MODULATION OF INTERLEUKIN-1 PRODUCTION BY MACROPHAGES FOLLOWING BENZO(A)PYRENE EXPOSURE
MODULATION OF INTERLEUKIN-1 PRODUCTION BY MACROPHAGES FOLLOWING BENZO(A)PYRENE EXPOSURE
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DOI：
10.1016/0192-0561(86)90120-7
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
BICK, PH
中科院分区：
文献类型：
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作者：
LYTE, M;BICK, PH
研究了环境致癌物苯并(A)芘(BaP)对体外培养的巨噬细胞分泌免疫调节分子白介素1(IL-1)的影响。在有BaP存在的巨噬细胞中，观察到内毒素刺激的IL-1产生呈剂量依赖性增加，同时伴随着细胞存活率的下降。外源性白介素1可以在体外重建在BaP剂量下被抑制的抗体反应。提示BaP免疫抑制的细胞靶点之一可能是巨噬细胞-单核细胞系的细胞。此外，BaP诱导的抗体反应性抑制可能是IL-1产生改变的结果。
The effects of benzo(a)pyrene(BaP), a highly prevalent environmental carcinogen, on the ability of peritoneal exudate macrophages to produce the secretory immunomodulatory molecule interleukin-1 (IL-1) in vitro was examined. A dose-dependent increase in lipopolysaccharide stimulated IL-1 production concomitant with decreased cell viabilities was noted in macrophages cultured in the presence of BaP. Antibody responses which are suppressed in BaP dosed mice can be reconstituted in vitro by the addition of exogenous interleukin-1. These results indicate that one of the cellular targets of BaP induced immunosuppression may be cells of the macrophage-monocyte lineage. Furthermore, BaP induced suppression of antibody responsiveness may be a result of alterations in production of IL-1.