Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation
Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation
复制标题
DOI：
10.1128/iai.01254-06
复制
发表时间：
2007-02-01
影响因子：
3.1
通讯作者：
Kawula, Thomas H.
中科院分区：
文献类型：
--
作者：
Hall, Joshua D.;Craven, Robin R.;Kawula, Thomas H.
土拉热弗朗西丝菌在巨噬细胞和树突状细胞中复制，但与其他细胞类型的相互作用尚未得到很好的描述。F.土拉菌LVS在肺泡上皮细胞系中侵袭和复制。经鼻内接种C57 BL/6小鼠后，弗朗西斯菌定位于肺泡，并在肺泡II型上皮细胞内复制。
Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.