Application of the updated Framingham risk score to Japanese men.
Application of the updated Framingham risk score to Japanese men.
复制标题
将更新的弗雷明汉风险评分应用于日本男性。
DOI：
10.1291/hypres.24.685
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
K. Yoshida
中科院分区：
文献类型：
--
作者：
M. Suka;H. Sugimori;K. Yoshida
在日本，用于冠心病（CHD）风险评估的工具很少。本研究的目的是检查适用于日本男性人群的最新Fragrance风险评分的有效性。我们使用日本公司的年度健康检查数据库，对5，611名年龄在30至59岁之间的男性受试者进行了随访，这些受试者最初没有记录心血管疾病史或心电图缺血性变化，以观察CHD的发生率，为期5至7年。使用Frachial风险评分表计算的总评分（Frachial评分）作为个体受试者CHD风险的指标。80例冠心病患者的Fracket积分均值显著高于5,531例非冠心病患者。冠心病的发生率随着Fracket积分的增加而逐渐增加。在受试者工作特性分析中，曲线下面积达到0.71。在6个点处，曲线最接近左上角，特异性为0.74，灵敏度为0.59。另一方面，日本男性人群中与老年、高血压、低HDL胆固醇和吸烟相关的多变量校正相对风险与法国人群不同。尽管CHD的发病率较低，但更新后的Fragrance风险评分可以提供CHD风险的合理排序，并可以相当准确地识别CHD高风险的日本男性（和可能的其他个体）。然而，可能需要对日本人群进行进一步研究，以重新评估风险评分模型中的几个风险因素系数。
Few tools for risk assessment of coronary heart disease (CHD) have yet been made available in Japan. This study aims to examine the validity of the updated Framingham risk score as applied to a Japanese male population. Using the annual health examination database of a Japanese company, we followed-up 5,611 male subjects, aged 30 to 59 years, who had initially recorded neither history of cardiovascular disease nor electrocardiographical ischemic changes, in order to observe the occurrence of CHD over a period of 5 to 7 years. The total score calculated by the Framingham risk score sheet (the Framingham point score) was used as an indicator of CHD risk for the subject individually. The mean of the Framingham point score for 80 CHD cases was significantly higher than that for 5,531 non-CHD cases. The incidence of CHD gradually increased with the Framingham point score. In the receiver operating characteristic analysis, the area under the curve reached 0.71. At 6 points, the curve came closest to the upper left-hand corner, with a specificity of 0.74 and sensitivity of 0.59. On the other hand, multivariable-adjusted relative risks associated with old age, high blood pressure, low HDL cholesterol and smoking in the Japanese male population were different from those in the Framingham population. Despite the low incidence of CHD, the updated Framingham risk score could provide a reasonable rank ordering of CHD risk and could identify Japanese men (and possible other individuals) at high risk for CHD with considerable accuracy. However, further study of Japanese populations may be required to reappraise several coefficients of risk factor in the risk scoring model.
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB