Roles of Copper-Binding Proteins in Breast Cancer.
Roles of Copper-Binding Proteins in Breast Cancer.
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DOI：
10.3390/ijms18040871
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发表时间：
2017-04-20
影响因子：
5.6
通讯作者：
Wittung-Stafshede P
中科院分区：
文献类型：
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作者：
Blockhuys S;Wittung-Stafshede P
铜离子在癌症进展的几个步骤中是必需的。然而，潜在的机制，并涉及铜结合蛋白，主要是难以捉摸的。由于体内（细胞内外）的大多数铜离子都与蛋白质结合，因此研究哪些铜结合蛋白参与其中以及它们如何通过铜转运蛋白装载铜是很重要的。一些铜结合蛋白，如细胞外赖氨酰氧化酶（LOX），在癌症中发挥作用的机制信息已被阐明，但仍然有很多从生物物理分子的观点来学习。在这里，我们提供了一个铜结合蛋白的总结，并讨论了报告有癌症的作用。我们特别关注铜结合蛋白，如细胞运动介质1（MEMO 1），LOX，LOX样蛋白，以及分泌的酸性和富含半胱氨酸的蛋白质（CYP 1A 1）如何从分子和临床方面调节乳腺癌。由于铜对侵袭/迁移过程的重要性，这是癌症转移的关键组成部分，进一步了解铜结合蛋白的作用可能会提供新的靶点来对抗癌症。
Copper ions are needed in several steps of cancer progression. However, the underlying mechanisms, and involved copper-binding proteins, are mainly elusive. Since most copper ions in the body (in and outside cells) are protein-bound, it is important to investigate what copper-binding proteins participate and, for these, how they are loaded with copper by copper transport proteins. Mechanistic information for how some copper-binding proteins, such as extracellular lysyl oxidase (LOX), play roles in cancer have been elucidated but there is still much to learn from a biophysical molecular viewpoint. Here we provide a summary of copper-binding proteins and discuss ones reported to have roles in cancer. We specifically focus on how copper-binding proteins such as mediator of cell motility 1 (MEMO1), LOX, LOX-like proteins, and secreted protein acidic and rich in cysteine (SPARC) modulate breast cancer from molecular and clinical aspects. Because of the importance of copper for invasion/migration processes, which are key components of cancer metastasis, further insights into the actions of copper-binding proteins may provide new targets to combat cancer.