Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
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DOI：
10.1016/j.cell.2008.05.054
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发表时间：
2008-08-08
期刊：
影响因子：
64.5
通讯作者：
Hensch, Takao K.
中科院分区：
文献类型：
--
作者：
Sugiyama, Sayaka;Di Nardo, Ariel A.;Hensch, Takao K.
神经回路是由出生后早期的经验塑造的。视觉皮质内不同的GABA能连接决定了重新连接眼睛优势以建立视力的关键期的时机。我们发现，控制可塑性开始的小白蛋白(PV)细胞网络的成熟是由胚胎OTX2同源蛋白的选择性重新表达调节的。视觉体验促进了非细胞自主的OTX2在PV细胞中的积累，皮质注射外源OTX2促进了PV细胞的发育和关键期的选择。相反，有条件地从非PV细胞或视觉通路中移除OTX2会消除可塑性。因此，依赖经验的同源蛋白转移可能为神经回路的出生后可塑性建立生理环境。
Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing. Conversely, conditional removal of Otx2 from non-PV cells or from the visual pathway abolished plasticity. Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.