EFFECTS OF THE IMMUNOMODULATOR PSK ON GROWTH OF HUMAN-PROSTATE ADENOCARCINOMA IN IMMUNODEFICIENT MICE
EFFECTS OF THE IMMUNOMODULATOR PSK ON GROWTH OF HUMAN-PROSTATE ADENOCARCINOMA IN IMMUNODEFICIENT MICE
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DOI：
10.1016/0192-0561(89)90137-9
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
FOULKES, K
中科院分区：
文献类型：
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作者：
MICKEY, DD;BENCUYA, PS;FOULKES, K
使用免疫调节剂PSK研究肿瘤生长的变化。在两种类型的免疫缺陷小鼠体内生长了四种人前列腺肿瘤细胞系。其中两个品系之所以被选中，是因为它们能够在宿主动物体内转移到肺部。以自然杀伤细胞正常的近交系瑞士无性系小鼠和自然杀伤细胞缺乏的无性系褐系小鼠为动物宿主。一些动物在实体瘤注射后不久接受PSK治疗，另一些动物在实体瘤完全建立后给予PSK治疗。一些动物给予小剂量环磷酰胺以减少宿主自然杀伤细胞，而另一些动物则给予多聚肌苷多胞苷(Poly I：C)以提高自然杀伤细胞活性。对肿瘤倍增时间、宿主存活和转移能力的测量表明，在注射肿瘤细胞后不久，在NIH瑞士动物中进行PolyI：C或PSK治疗都显著增加了肿瘤加倍时间和宿主存活，并降低了肺转移灶的发生率和数量。其中两个在NIH瑞士小鼠身上不能转移的肿瘤系在Biege Anymic，自然杀伤细胞缺陷的动物中转移。
Tumor growth alterations were studied using an immunomodulator, PSK. Four human prostate tumor lines were grown in two types of immunodeficient mice. Two of the lines were selected because they are able to metastasize to lungs in host animals. Outbred HIN Swiss athymic mice having normal natural killer cells and athymic Beige mice deficient in natural killer cells were used as animal hosts. PSK treatment was given to tumor-bearing hosts to some animals soon after solid tumors were injected and to others after solid tumors were well-established. Low dose cyclophosphamide was given to some animals to decrease host natural killer cells and polyinosinic-polycytidylic acid (poly I:C) was given to other animals to increase natural killer cell activity. Measurement of tumor doubling times, host survival and metastatic capabilities showed that either poly I:C or PSK treatment in NIH Swiss animals soon after tumor cells were injected significantly increased tumor doubling times and host survival and decreased the incidence and number of metastatic lung lesions. Two of the tumor lines incapable of metastasizing in NIH Swiss mice were metastatic in the Biege athymic, natural killer-cell-deficient animals.