The biology and synthesis of α-hydroxytropolones.
The biology and synthesis of α-hydroxytropolones.
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DOI：
10.1039/c4md00055b
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发表时间：
2014-07-01
期刊：
影响因子：
--
通讯作者：
Murelli RP
中科院分区：
文献类型：
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作者：
Meck C;D'Erasmo MP;Hirsch DR;Murelli RP
α-羟基tropolones是天然产物troponoid家族的一个亚类，由于其广泛的生物活性和作为多种疾病治疗选择的潜力而受到高度关注。尽管有这样的前景，但很少有合成化学驱动的分子优化研究。以下综述了迄今为止对α-羟基邻苯二酮进行的生物学研究的主要进展，包括一些合成化学驱动的优化研究。此外，我们还概述了目前可用于获取这些分子的方法。本文旨在为研究α-羟基邻苯二酮类化合物的生物活性提供参考，并为进一步研究α-羟基邻苯二酮类化合物提供新的合成方法和策略。
α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce synthetic chemistry-driven optimization studies on the molecules. The following review highlights key developments in the biological studies conducted on α-hydroxytropolones to date, including the few synthetic chemistry-driven optimization studies. In addition, we provide an overview of the methods currently available to access these molecules. This review is intended to serve as a resource for those interested in biological activity of α-hydroxytropolones, and inspire the development of new synthetic methods and strategies that could aid in this pursuit.