Prospective clinical evaluation of the serologic tuberculous glycolipid test in combination with the nucleic acid amplification test
Prospective clinical evaluation of the serologic tuberculous glycolipid test in combination with the nucleic acid amplification test
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DOI：
10.1128/jcm.41.3.1322-1325.2003
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发表时间：
2003-03-01
影响因子：
9.4
通讯作者：
Yano, I
中科院分区：
文献类型：
--
作者：
Maekura, R;Kohno, H;Yano, I
我们进行了一项前瞻性对照多中心研究，以评估结核糖脂（TBGL）血清学诊断试验和核酸扩增试验在涂片阴性活动性肺结核（TB）患者中的临床应用水平差异。TBGL试验和PCR试验对痰涂片阴性活动性肺结核的快速诊断并不十分有用。然而，TBGL试验和PCR试验联合使用可显著提高临床实用性，特别是在涂片阴性和培养阴性的活动性肺结核患者和最小晚期病变患者中。
We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions.