Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models
Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models
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DOI：
10.7554/elife.20047
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发表时间：
2016-12-22
期刊：
影响因子：
7.7
通讯作者：
Bestmann, Sven
中科院分区：
文献类型：
--
作者：
Bonaiuto, James J.;de Berker, Archy;Bestmann, Sven
动物和人类都倾向于重复最近的选择，这种现象被称为选择滞后。这种选择偏差的机制尚不清楚。利用一个已建立的、生物物理信息完备的竞争吸引子网络决策模型，我们发现，在之前的试验中，尾部活动的衰减导致了选择滞后，特别是在困难的试验中，并准确地预测了人类的感知选择。在模型中，选择可变性可以通过模拟去极化或超极化网络刺激放大或抑制试验后的活动衰减来定向改变。在左背外侧前额叶皮质（dlPFC）上使用经颅直流电刺激（tDCS）进行类似的干预，模型预测和实验结果非常吻合：净体细胞去极化电流增加了选择迟滞，而超极化电流抑制了选择迟滞。因此，dlPFC内竞争吸引物网络的残留活动可能会导致感知选择的偏差，这可以通过非侵入性脑刺激进行定向控制。
Animals and humans have a tendency to repeat recent choices, a phenomenon known as choice hysteresis. The mechanism for this choice bias remains unclear. Using an established, biophysically informed model of a competitive attractor network for decision making, we found that decaying tail activity from the previous trial caused choice hysteresis, especially during difficult trials, and accurately predicted human perceptual choices. In the model, choice variability could be directionally altered through amplification or dampening of post-trial activity decay through simulated depolarizing or hyperpolarizing network stimulation. An analogous intervention using transcranial direct current stimulation (tDCS) over left dorsolateral prefrontal cortex (dlPFC) yielded a close match between model predictions and experimental results: net soma depolarizing currents increased choice hysteresis, while hyperpolarizing currents suppressed it. Residual activity in competitive attractor networks within dlPFC may thus give rise to biases in perceptual choices, which can be directionally controlled through non-invasive brain stimulation.