The use of bacteriophages of the family Cystoviridae as surrogates for H5N1 highly pathogenic avian influenza viruses in persistence and inactivation studies
The use of bacteriophages of the family Cystoviridae as surrogates for H5N1 highly pathogenic avian influenza viruses in persistence and inactivation studies
复制标题
DOI：
10.1080/10934520903217054
复制
发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Swayne, David E.
中科院分区：
文献类型：
--
作者：
Adcock, Noreen J.;Rice, Eugene W.;Swayne, David E.
在水中的持久性和氯灭活研究中，对两种噬菌体 phi 6 和 phi 8 作为 H5N1 高致病性禽流感病毒的潜在替代物进行了研究。在持久性研究中，在 17 摄氏度和 28 摄氏度的淡水中，phi 6 和 phi 8 的传染性至少与 H5N1 病毒一样长，但在盐水中结果有所不同。噬菌体 phi 6 还表现出比 H5N1 病毒稍高的耐氯性。基于这些发现，噬菌体可能有潜力用作淡水中持久性和灭活研究的替代物。
Two bacteriophages, phi 6 and phi 8, were investigated as potential surrogates for H5N1 highly pathogenic avian influenza virus in persistence and chlorine inactivation studies in water. In the persistence studies, phi 6 and phi 8 remained infectious at least as long as the H5N1 viruses at both 17 and 28 degrees C in fresh water, but results varied in salinated water. The bacteriophage phi 6 also exhibited a slightly higher chlorine resistance than that of the H5N1 viruses. Based upon these findings, the bacteriophages may have potential for use as surrogates in persistence and inactivation studies in fresh water.