Homology-based fold predictions for Mycoplasma genitalium proteins
Homology-based fold predictions for Mycoplasma genitalium proteins
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DOI：
10.1006/jmbi.1998.1884
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发表时间：
1998-07-17
影响因子：
5.6
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Huynen, M;Doerks, T;Bork, P
基于迭代 PSI-BLAST 方法的同源搜索技术与低序列复杂性的各种过滤器相结合，用于为所有生殖支原体蛋白分配折叠。由此产生的程序（作为网络服务器实现）能够自动预测 37% 的这些蛋白质中的至少一个域，估计准确度高于 98%。撇开卷曲螺旋或跨膜区域等结构特征不谈，仅通过迭代序列比较就可以将折叠分配给细菌中一半以上的球状蛋白。 (C) 1998 年学术出版社。
Homology search techniques based on the iterative PSI-BLAST method in combination with various filters for low sequence complexity are applied to assign folds to all Mycoplasma genitalium proteins. The resulting procedure (implemented as a web server) is able to predict at least one domain in 37% of these proteins automatically, with an estimated accuracy higher than 98%. Taking structural features such as coiled coil or transmembrane regions aside, folds can be assigned to more than half of the globular proteins in a bacterium just by iterative sequence comparison. (C) 1998 Academic Press.