Correlation between serum uric acid and diabetic peripheral neuropathy in T2DM patients
Correlation between serum uric acid and diabetic peripheral neuropathy in T2DM patients
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T2DM患者血尿酸与糖尿病周围神经病变的相关性
DOI：
10.1016/j.jns.2017.11.034
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发表时间：
2018-02-15
影响因子：
4.4
通讯作者：
Pan, Suyue
中科院分区：
文献类型：
--
作者：
Lin, Xiaopu;Xu, Lingling;Pan, Suyue
目的探讨2型糖尿病（T2 DM）患者血尿酸（SUA）水平与糖尿病周围神经病变（DPN）的相关性。结果：不同SUA水平组运动/感觉神经波幅和传导速度（CV）参数差异均有统计学意义（P均< 0.05）; SUA水平与运动/感觉神经波幅均值和CV呈负相关（均P < 0.05）。病程> 10年、血尿酸> 9 mg/dl、总胆固醇（TC）> 5.2mmol/L与DPN的发生有显著相关性（P均< 0.05）。受试者工作特征（ROC）分析显示，T2 DM病程联合SUA和TC的截断点分别为9年、7.8 mg/dL和4.97 mmol/L（AUC = 0.65; 95%CI：0.53-0.77;敏感性，70.6%;特异性，65.2%，P = 0.009）。糖尿病病程、血尿酸和总胆固醇可能是预测糖尿病周围神经病变发生的重要指标。
Aim To investigate the correlation between serum uric acid (SUA) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients.Methods: Two hundred T2DM patients were divided into four groups at the cut-off points of 5, 7, and 9 mg/dL of SUA levels. Nerve conduction studies (NCS), Semmes-Weinstein monofilament testing (SWMT), and vibration perception threshold (VPT) tests were performed on these patients.Results: Significant differences in motor/sensory nerve amplitude and conduction velocity (CV) parameters among different SUA level groups were observed (all P < 0.05). SUA levels were negatively correlated with the means of motor/sensory nerve amplitude and CV (all P < 0.05). Duration of T2DM > 10 years, SUA > 9 mg/dl and total cholesterol (TC) > 5.2 mmol/L were found to be significantly associated with DPN (all P < 0.05). Receiver-operating characteristic (ROC) analysis revealed that the cut-off points of T2DM duration combined with SUA and TC were 9 years, 7.8 mg/dL, and 4.97 mmol/L, respectively (AUC = 0.65; 95% CI: 0.53-0.77; sensitivity, 70.6%; specificity, 65.2%, P = 0.009).Conclusion: There is a significant association between elevated SUA levels and DPN, and T2DM duration, SUA, and TC may be valuable indicators to predict the occurrence of DPN in T2DM patients.