Role of viruses in the loss of tolerance to self-antigens and in autoimmune diseases.
Role of viruses in the loss of tolerance to self-antigens and in autoimmune diseases.
复制标题
病毒在自身抗原耐受性丧失和自身免疫性疾病中的作用。
DOI：
10.1016/s0966-842x(00)88995-7
复制
发表时间：
1995
影响因子：
15.9
通讯作者：
Oldstone,MB
中科院分区：
文献类型：
--
作者：
vonHerrath,MG;Oldstone,MB
对自身抗原耐受的破坏，涉及自身反应性淋巴细胞的激活，是导致自身免疫性疾病的关键事件。发生这种情况的确切机制尚不清楚，但在其他病因中，病毒已被牵连。胰岛素依赖型糖尿病动物模型的最新结果为病毒如何诱导自身免疫性疾病提供了见解。
The breaking of tolerance to self-antigens, involving the activation of self-reactive lymphocytes, is a critical event leading to autoimmune disease. The precise mechanisms by which this occurs are unknown, but among other etiological factors, viruses have been implicated. Recent results with animal models of insulin-dependent diabetes provide insight into how viruses induce autoimmune disease.