SPECT findings on psychosis in Alzheimer's disease.
SPECT findings on psychosis in Alzheimer's disease.
复制标题
阿尔茨海默病精神病的 SPECT 结果。
DOI：
10.1176/ajp.152.10.1470
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Doody,R
中科院分区：
文献类型：
--
作者：
Kotrla,KJ;Chacko,RC;Harper,RG;Jhingran,S;Doody,R
本研究探讨是否与脑灌注模式明显单光子发射计算机断层扫描（SPECT）scans.MethodAll合作的门诊病人参加了阿尔茨海默氏病研究中心的诊断可能阿尔茨海默氏病和轻度或中度的临床痴呆症评级与他们的主要照顾者进行了采访。使用汉密尔顿抑郁评定量表、DSM-III-R结构化临床访谈和阿尔茨海默病行为病理评定量表评估当前和过去的精神功能。无病前精神病患者进行SPECT扫描，并与妄想或幻觉的患者（N= 30）的扫描与无这些症状的患者（N= 16）的扫描进行了比较。与幻觉的患者（N= 10）有低灌注在顶叶。ConclusionsPsychotic阿尔茨海默病患者的脑血流缺损的模式显着不同的非精神病患者。这表明，脑功能障碍的模式可能被表达为精神病。
ObjectiveThis study examined whether psychosis in Alzheimer's disease is associated with cerebral perfusion patterns appreciable by single photon emission computed tomography (SPECT) scans.MethodAll cooperative outpatients enrolled in an Alzheimer's disease research center with the diagnosis of probable Alzheimer's disease and a Clinical Dementia Rating of mild or moderate were interviewed with their primary caregivers. Current and past psychiatric functioning was assessed by using the Hamilton Depression Rating Scale, the Structured Clinical Interview for DSM-III-R, and the Behavioral Pathology in Alzheimer's Disease Rating Scale. Patients without premorbid psychosis received SPECT scans, and the scans of the patients with delusions or hallucinations (N= 30) were compared to the scans of patients without these symptoms (N= 16).ResultsThe patients with delusions (N= 29) had hypoperfusion of the left frontal lobe in relation to the right frontal lobe. The patients with hallucinations (N= 10) had hypoperfusion in the parietal lobe.ConclusionsPsychotic patients with Alzheimer's disease had a pattern of cerebral blood flow deficits significantly different from that of nonpsychotic patients. This suggests that patterns of cerebral dysfunction may be expressed symptomatically as psychosis.