Atrioventricular interactions: a theoretical simulation study.
Atrioventricular interactions: a theoretical simulation study.
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房室相互作用：理论模拟研究。
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
S. Sideman
中科院分区：
文献类型：
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作者：
R. Beyar;S. Sideman
基于左心房(LA)和左心室(LV)的结构和心肌特性，提出了一个描述复杂房室相互作用的定量模型。对LV的描述遵循了我们早期的研究，该研究假设LV为嵌套壳球形结构，具有扇形纤维角分布、跨壁电激活速度和肌纤维动力学，具有典型的肌节的被动和主动特征。本文对LV模型进行了扩展，包括了LV被动心肌的指数负荷依赖性松弛和粘性(应变率相关)特征。所提出的LA模型是基于具有随机纤维结构的薄壁球面几何结构。心房肌的特点与心室肌的不同之处在于，在被动状态下更硬，而在主动状态下更弱但更快。LV和LA室连接到预加载和后加载方案，并通过二尖瓣血流及其惯性特性相互连接。本文对LA和LV之间的复杂相互作用进行了深入的研究，计算结果与已有的实验数据相吻合。
A quantitative model that describes the complex atrioventricular interactions, based on the structure and myocardial properties of the left atrium (LA) and left ventricle (LV), is presented. The description of the LV follows our earlier study that assumes a nested-shell spheroidal structure with fanlike fiber angle distribution, transmural electrical activation velocity, and the muscle fiber dynamics with the classical passive and active features of the sarcomeres. The LV model is extended here to include an exponential load-dependent relaxation and viscous (strain rate-dependent) features of the LV passive myocardium. The proposed LA model is based on a thin-wall spherical geometry with a random fibrous structure. The atrial muscle features differ from the ventricular muscle by being much stiffer in the passive state and weaker but faster in the active state. The LV and LA compartments are connected to a preload and afterload scheme and interconnected by the mitral flow with its inertial properties. The complex interactions between the LA and the LV are thoroughly studied here, and the calculated results are consistent with well-established experimental data.