CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis.
CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis.
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CRM1，一种在预后不良的浸润性乳腺癌中过度表达的新型独立预后因素
DOI：
10.3892/ol.2018.8316
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发表时间：
2018-05
期刊：
影响因子：
2.9
通讯作者：
Niu HT
中科院分区：
文献类型：
--
作者：
Yue L;Sun ZN;Yao YS;Shen Z;Wang HB;Liu XP;Zhou F;Xiang JY;Yao RY;Niu HT
乳腺癌(BC)是全球女性中最常见的癌症，在晚期更具侵袭性。染色体区域维护1(CRM1)参与蛋白质和RNA的核输出，并与许多恶性肿瘤有关。然而，其在BC中的表达的临床病理意义仍有待阐明，因此本研究对此进行了探讨。采用免疫组织化学(IHC)和Western blotting方法，对280例乳腺癌组织和60例正常乳腺组织中CRM1的表达进行了回顾性分析。免疫组织化学研究显示，与正常乳腺组织相比，BC组织中CRM1的表达显著增加(P<；0.0001)。肿瘤体积较大(P=0.024)、有无淋巴结转移(P=0.032)、侵袭性组织学类型(P=0.004)和远处转移(P=0.026)与CRM1过度表达显著相关。CRM1的表达增加与孕激素受体(P=0.028)和Ki67(P=0.019)之间也有显著的相关性。Kaplan-Meier生存分析显示，与低表达患者相比，高表达患者的无病生存期和总生存期均降低(P=0.013)。在多因素分析中，CRM1的表达(P=0.011)、肿瘤大小(P=0.001)和淋巴结转移(P<；0.001)是影响BC预后的独立指标。总之，CRM1在BC中起着重要作用，可作为BC患者预后不良的预测和预后因素。
Breast cancer (BC) is the most commonly diagnosed cancer in females globally and is more aggressive at later stages. Chromosome region maintenance 1 (CRM1) is involved in the nuclear export of proteins and RNAs and has been associated with a number of malignancies. However, the clinicopathological significance of its expression in BC remains to be elucidated therefore this was investigated in the present study. CRM1 expression in 280 breast cancer tissues and 60 normal tissues was retrospectively analyzed using immunohistochemistry (IHC) and western blotting. IHC investigation demonstrated that CRM1 expression was significantly increased in BC compared with the normal breast epithelium (P<0.0001). Overexpression of CRM1 was markedly associated with poor prognostic characteristics, including larger tumor size (P=0.024), positive lymph node metastasis (P=0.032), invasive histological type (P=0.004) and distant metastasis (P=0.026). Significant associations were also observed between increased CRM1 expression and the progesterone receptor (P=0.028) and Ki67 (P=0.019). Kaplan-Meier survival analysis demonstrated that patients with high CRM1 expression exhibited a reduced disease-free survival and overall survival compared with those with low CRM1 expression (P=0.013). In the multivariate analysis, CRM1 expression (P=0.011), tumor size (P=0.001) and lymph node metastasis (P<0.001) were independent prognostic markers of BC. In conclusion, CRM1 serves an important role in BC and may serve as a predictive and prognostic factor for a poor outcome in patients with BC.
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影响因子：
28.5
作者：
Parikh K;Cang S;Sekhri A;Liu D
通讯作者：
Liu D
影响因子：
64.5
作者：
Fornerod, M;Ohno, M;Mattaj, IW
通讯作者：
Mattaj, IW
影响因子：
29.4
作者：
Azmi AS;Aboukameel A;Bao B;Sarkar FH;Philip PA;Kauffman M;Shacham S;Mohammad RM
通讯作者：
Mohammad RM
影响因子：
4.8
作者：
Shen, Aiguo;Wang, Yuchan;Cheng, Chun
通讯作者：
Cheng, Chun
DOI：
10.1073/pnas.96.16.9112
发表时间：
1999-08-03
影响因子：
11.1
作者：
Kudo, N;Matsumori, N;Horinouchi, S
通讯作者：
Horinouchi, S