Roles of connexins and pannexins in digestive homeostasis.
Roles of connexins and pannexins in digestive homeostasis.
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DOI：
10.1007/s00018-015-1961-8
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Vinken M
中科院分区：
文献类型：
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作者：
Maes M;Cogliati B;Crespo Yanguas S;Willebrords J;Vinken M
连接蛋白在消化系统中大量存在。它们主要形成间隙连接，控制关键稳态调节因子的细胞间交换。通过这样做，间隙连接驱动了大量的胃肠道和肝脏功能特征，包括胃和肠道运动、胃酸分泌、肠道先天免疫防御、异种生物转化、糖原分解、胆汁分泌、氨解毒和血浆蛋白合成。在过去的十年中，人们已经清楚地认识到连接蛋白半通道，作为间隙连接的结构前体，也为细胞通信提供了途径，即细胞质和细胞外环境之间的通信。虽然仅描述了病理功能，但一些生理作用已归因于连接蛋白半通道，特别是在结肠运动的调节中。这同样适用于由泛连接蛋白组成的细胞通道，泛连接蛋白是最近在肠道和肝脏中发现的连接蛋白样蛋白质，已成为炎症过程中公认的关键角色，并被认为可以控制结肠运动、分泌和血液流动。
Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate immune defense, xenobiotic biotransformation, glycogenolysis, bile secretion, ammonia detoxification and plasma protein synthesis. In the last decade, it has become clear that connexin hemichannels, which are the structural precursors of gap junctions, also provide a pathway for cellular communication, namely between the cytosol and the extracellular environment. Although merely pathological functions have been described, some physiological roles have been attributed to connexin hemichannels, in particular in the modulation of colonic motility. This equally holds true for cellular channels composed of pannexins, connexin-like proteins recently identified in the intestine and the liver, which have become acknowledged key players in inflammatory processes and that have been proposed to control colonic motility, secretion and blood flow.