Does neurofilament phosphorylation regulate axonal transport?
Does neurofilament phosphorylation regulate axonal transport?
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DOI：
10.1016/s0166-2236(03)00199-1
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发表时间：
2003-08-01
影响因子：
15.9
通讯作者：
Pant, HC
中科院分区：
文献类型：
--
作者：
Shea, TB;Jung, CL;Pant, HC
长期以来，神经丝的磷酸化被认为是调节其轴突运输速率，并在此过程中为成熟轴突提供稳定性。最近获得的C-末端缺失实验后的数据的解释，促使这一假设的挑战。我们目前的证据表明，这些删除研究仍然是一致的，而不是反驳，C-末端磷酸化的作用，在调节神经丝轴突运输。
Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.