Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation
Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation
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DOI：
10.1152/ajpregu.00339.2006
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发表时间：
2007-05-01
影响因子：
2.8
通讯作者：
Covasa, Mihai
中科院分区：
文献类型：
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作者：
De Jonghe, Bart C.;Hajnal, Andras;Covasa, Mihai
大冢Long-Evans德岛脂肪（OLETF）大鼠是LongEvans德岛大冢大鼠（LETO）的远交品系，其缺乏CCK-1受体表达，是过度吞噬的并且发展肥胖和2型糖尿病。本研究旨在评估OLETF大鼠在急性食物剥夺后如何改变可口溶液的摄入量、偏好和条件偏好。我们的研究结果表明，在24它的食物限制，LETO大鼠增加蔗糖摄入量和两瓶蔗糖偏好相对于他们的自由喂养的基线，而OLETF大鼠不增加蔗糖摄入量（0.3 M或1.0 M蔗糖）或偏好（1.0 M与0.3 M蔗糖）时，他们被剥夺食物。相比之下，当蔗糖用作非条件刺激（US）时，OLETF大鼠相对于LETO大鼠表现出更高的条件风味偏好，无论是在测试期间限制过夜食物（对于OLETF和LETO大鼠分别为81%对71%）还是自由进食（对于OLETF和LETO大鼠分别为82%对54%）。当使用无热量的糖精溶液作为US时，OLETF大鼠在非剥夺时相对于LETO大鼠表现出对糖精相关风味的更高偏好（OLETF和LETO大鼠分别为76%和58%）;然而，在测试期间，两种品系都没有表现出对糖精在剥夺状态下的差异条件风味偏好。这些结果表明，OLETF大鼠未能整合后吸收和orosensory蔗糖在条件设置的影响摄入的影响。因此，看起来OLETF大鼠形成对蔗糖的偏好主要基于溶液的口腔感觉和享乐性质，而不是卡路里值。
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an outbred strain of LongEvans Tokushima Otsuka rat (LETO) that lacks CCK-1 receptor expression, is hyperphagic and develops obesity and type-2 diabetes. The present study sought to assess how OLETF rats alter intake, preference, and conditioned preference of palatable solutions after acute food deprivation. Our results show that after 24 It chow restriction, LETO rats increase both sucrose intake and two-bottle sucrose preference relative to their free-fed baseline, whereas OLETF rats do not increase sucrose intake (0.3 M or 1.0 M sucrose) or preference (1.0 M vs. 0.3 M sucrose) when they are food deprived. In contrast, OLETF rats exhibit a higher conditioned flavor preference when sucrose is used as unconditioned stimulus (US) relative to LETO rats, whether overnight food restricted (81% vs. 71 % for OLETF and LETO rats, respectively) or free fed (82% vs. 54% for OLETF and LETO rats, respectively) during the test. When a noncaloric saccharin solution is used as US, OLETF rats show a higher preference for the saccharin-associated flavor relative to LETO rats when nondeprived (76% vs. 58% for OLETF and LETO rats, respectively); however, neither strain shows differential conditioned flavor preference for saccharin in the deprivation state during the test. These findings suggest that OLETF rats fail to integrate postabsorpfive and orosensory effects of sucrose in a conditioning setting to influence intake. Thus, it appears that OLETF rats form preferences for sucrose based largely on orosensory and hedonic properties o I e solution, rather than caloric value.