CUTANEOUS MECHANICAL SENSORY STIMULATION INCREASES EXTRACELLULAR ACETYLCHOLINE-RELEASE IN CEREBRAL-CORTEX IN ANESTHETIZED RATS
CUTANEOUS MECHANICAL SENSORY STIMULATION INCREASES EXTRACELLULAR ACETYLCHOLINE-RELEASE IN CEREBRAL-CORTEX IN ANESTHETIZED RATS
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DOI：
10.1016/0197-0186(92)90194-v
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发表时间：
1992-10-01
影响因子：
4.2
通讯作者：
SATO, Y
中科院分区：
文献类型：
--
作者：
KUROSAWA, M;SATO, A;SATO, Y
采用微透析技术研究了氟烷麻醉大鼠各节段皮肤区域（面部、前肢和前爪、背部、后肢和前爪）的有害和无害机械刺激对顶叶大脑皮层细胞外乙酰胆碱释放的影响。捏前爪或后爪并刷后肢10分钟可显著增加细胞外乙酰胆碱释放，而捏脸或背部并刷脸、前肢或背部则无显著变化。这些结果表明，皮肤感觉刺激可以调节大脑皮层细胞外乙酰胆碱的释放，并且刺激对皮层乙酰胆碱释放的效果依赖于感觉方式和受刺激皮肤的区域。
The effects of noxious and innocuous mechanical stimulation of various segmental skin areas (face, forelimb and paw, back, hindlimb and paw) on extracellular acetylcholine release in the cerebral cortex in the parietal lobe were examined in halothane-anesthetized rats, by means of the microdialysis technique. Pinching of a forepaw or hindpaw and brushing of a hindlimb for 10 min produced significant increases in extracellular acetylcholine release, whereas pinching of the face or back and brushing of the face, forelimb or back produced no significant changes. These results demonstrate that cutaneous sensory stimulation can regulate extracellular acetylcholine release in the cerebral cortex, and that the efficacy of the stimulation on cortical acetylcholine release is dependent on the sensory modality and the region of skin stimulated.