Block copolymer micelles: preparation, characterization and application in drug delivery
Block copolymer micelles: preparation, characterization and application in drug delivery
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DOI：
10.1016/j.jconrel.2005.09.034
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发表时间：
2005-12-05
影响因子：
10.8
通讯作者：
Leroux, JC
中科院分区：
文献类型：
--
作者：
Gaucher, G;Dufresne, MH;Leroux, JC
嵌段共聚物胶束通常由两亲性或相反电荷的共聚物在水介质中的自组装形成。亲水性和疏水性块分别形成胶束的电晕和核心。非离子水溶性外壳的存在以及聚合物胶束的尺度（10-100 nm）预计将限制它们被单核吞噬细胞系统吸收，并通过增强的渗透和保留效应允许被动靶向癌变或炎症组织。该领域的研究越来越多地集中在提高胶束组装的稳定性，延长循环时间和控制药物的释放以达到最佳靶向。考虑到这一点，我们的团队已经开发了一系列用于各种应用的嵌段共聚物，包括用于化疗药物被动靶向的两亲性胶束和用于口服递送低生物利用度化合物的环境敏感胶束。在此，我们将回顾嵌段共聚物合成、聚合物胶束制备和表征方面的创新，以及这些发展与生物医学研究领域的相关性。(c) 2005 Elsevier B.V.版权所有
Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10-100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect. Research in the field has been increasingly focused on achieving enhanced stability of the micellar assembly, prolonged circulation times and controlled release of the drug for optimal targeting. With that in mind, our group has developed a range of block copolymers for various applications, including amphiphilic micelles for passive targeting of chemotherapeutic agents and environment-sensitive micelles for the oral delivery of poorly bioavailable compounds. Here, we propose to review the innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research. (c) 2005 Elsevier B.V. All rights reserved.