Metal-enhanced emission from indocyanine green:: a new approach to in vivo imaging
Metal-enhanced emission from indocyanine green:: a new approach to in vivo imaging
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DOI：
10.1117/1.1578643
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发表时间：
2003-07-01
影响因子：
3.5
通讯作者：
Lakowicz, JR
中科院分区：
文献类型：
--
作者：
Malicka, J;Gryczynski, I;Lakowicz, JR
吲哚菁绿（ICG）广泛应用于医学成像和检测。其复杂的光谱行为和低量子产率限制了一些应用。我们表明，ICG 靠近金属银颗粒时，其强度会增加约 20 倍，并会缩短衰减时间。由于光漂白率没有增加，我们的结果表明，ICG-银颗粒复合物可以使每个 ICG 分子产生至少 20 倍以上的光子，从而改善医学成像。 (C) 2003 年光电仪器工程师协会。
Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging. (C) 2003 Society of Photo-Optical Instrumentation Engineers.