The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats
The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats
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DOI：
10.1016/j.lfs.2003.09.055
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发表时间：
2004-03-19
期刊：
影响因子：
6.1
通讯作者：
Koo, MWL
中科院分区：
文献类型：
--
作者：
Cheng, CL;Guo, JS;Koo, MWL
本研究考察了积雪草水提物（CE）及其活性成分积雪草苷（AC）对醋酸致大鼠胃溃疡（接吻溃疡）的愈合作用。以积雪草干植物为原料，采用高效液相色谱法定量测定了积雪草中AC的含量。对患有接吻溃疡的大鼠口服不同浓度的CE和AC。他们发现在第3天和第7天以剂量依赖的方式减少溃疡的大小，并伴随溃疡组织的髓过氧化物酶活性的衰减。另一方面，促进上皮细胞增殖和血管生成。CE和AC处理大鼠的溃疡组织中，碱性成纤维细胞生长因子（一种重要的血管生成因子）的表达也上调。这些结果进一步提示积雪草及其有效成分作为抗胃溃疡药物的潜在应用价值。(C) 2004爱思唯尔公司版权所有。
In this study, the healing effects of Centella asiatica water extract (CE) and asiaticoside (AC), an active constituent of CE, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE and AC were orally administered to rats with kissing ulcers. They were found to reduce the size of the ulcers at day 3 and 7 in a dose-dependent manner, with a concomitant attenuation of myeloperoxidase activity at the ulcer tissues. Epithelial cell proliferation and angiogenesis were on the other hand promoted. The expression of basic fibroblast growth factor, an important angiogenic factor, was also upregulated in the ulcer tissues in rats treated with CE or AC. These results further suggest the potential use of Centella asiatica and its active ingredient as anti-gastric ulcers drugs. (C) 2004 Elsevier Inc. All rights reserved.