Vitamin E and Alzheimer's disease: the mediating role of cellular aging
Vitamin E and Alzheimer's disease: the mediating role of cellular aging
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DOI：
10.1007/s40520-019-01209-3
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发表时间：
2020-03-01
影响因子：
4
通讯作者：
Arosio, Beatrice
中科院分区：
文献类型：
--
作者：
Casati, Martina;Boccardi, Virginia;Arosio, Beatrice
维生素E是一种有效的抗氧化和抗炎系统，在阿尔茨海默病（AD）中发挥作用。与认知健康的受试者相比，在AD患者中观察到不同形式的维生素E血浆浓度。由于这些修饰可能调节氧化应激和细胞衰老的标志物，我们的目的是探索维生素E形式与AD中白细胞端粒长度（LTL）之间的关系。方法纳入53例AD患者和40例认知健康对照。测定了维生素E的形态（α -、β -、γ -和-生育酚，α -、β -、γ -和-生育三烯醇），α -生育酚醌/ α -生育酚和5-硝基-生育酚/ γ -生育酚（氧化/亚硝化损伤标志物）和LTL。结果与讨论采用回归模型探讨维生素E形式和LTL与AD的关系。研究了LTL在维生素E形式与AD之间的相互作用。与ct相比，AD受试者的α -、β -、α -和-生育酚、α -和-生育三烯醇、总生育酚、总生育三烯醇和总维生素E的浓度显著降低。AD受试者表现出较高的亚硝化/氧化损伤值。调整后的分析证实，AD与血浆中α -和β -生育酚、δ -生育三烯醇、总生育酚、总生育三烯醇、总维生素E和氧化/亚硝化损伤的浓度有显著关系。然而，亚硝化损伤仅在LTL较高的受试者中与AD显著相关，而在表达明显细胞衰老的受试者中则没有。我们的研究证实了维生素E在AD病理中的作用，并表明亚硝化损伤仅在LTL较长的受试者中影响与AD的关联。
Background Vitamin E represents a potent antioxidant and anti-inflammatory system, playing a role in Alzheimer's disease (AD). Different plasma concentrations of the forms of vitamin E are observed in AD compared to cognitively healthy subjects. Aim Since these modifications may modulate the markers of oxidative stress and cellular aging, we aim to explore the relationship between vitamin E forms and leukocyte telomere length (LTL) in AD. Methods 53 AD subjects and 40 cognitively healthy controls (CTs) were enrolled. The vitamin E forms (alpha-, beta-, gamma- and delta-tocopherol, alpha-, beta-, gamma- and delta-tocotrienol), the ratio of alpha-tocopherylquinone/alpha-tocopherol and 5-nitro-gamma-tocopherol/gamma-tocopherol (markers of oxidative/nitrosative damage) and LTL were measured. Results and discussion Regression model was used to explore the associations of vitamin E forms and LTL with AD. The interaction of LTL in the association between vitamin E forms and AD was tested. AD subjects showed significantly lower concentrations of alpha-, beta-, gamma- and delta-tocopherol, alpha- and delta-tocotrienol, total tocopherols, total tocotrienols and total vitamin E compared to CTs. AD subjects showed higher values of nitrosative/oxidative damage. The adjusted analyses confirmed a significant relationship of AD with plasma concentrations of alpha- and beta-tocopherols, delta-tocotrienol, total tocopherols, total tocotrienol, total vitamin E and oxidative/nitrosative damage. However, nitrosative damage was significantly associated with AD only in subjects with higher LTL and not in those expressing marked cellular aging. Conclusions Our study confirms the role of vitamin E in AD pathology and indicates that nitrosative damage influences the association with AD only in subjects characterized by longer LTL.