Recombinant luteinizing hormone priming in early follicular phase for women undergoing in vitro fertilization: Systematic review and meta-analysis
Recombinant luteinizing hormone priming in early follicular phase for women undergoing in vitro fertilization: Systematic review and meta-analysis
复制标题
DOI：
10.1177/0300060513509044
复制
发表时间：
2014-04-01
影响因子：
1.6
通讯作者：
Sun, Yingpu
中科院分区：
文献类型：
--
作者：
Hu, Linli;Bu, Zhiqin;Sun, Yingpu
目的探讨卵泡早期补充重组人促黄体生成素(Rlh)对体外受精(IVF)和卵胞浆内单精子注射(ICSI)结局的影响。方法采用系统回顾和Meta分析的方法，对体外受精/卵胞浆内单精子注射(IVF/ICSI)进行系统回顾和Meta分析。检索MEDLINE(R)、EMBASE和Cochrane临床试验数据库，无语言限制，但限于随机对照试验(RCT)。结果3个随机对照试验(RCT)346例患者进入Meta分析，表明RLH术前注射不会增加持续妊娠率。尽管在人绒毛膜促性腺激素注射日，rLH预处理组所需重组卵泡刺激素(RFSH)较少，而雌二醇水平较高，但rLH预处理组与单纯rFSH组相比，获卵数和胚胎数无明显差异。结论本系统回顾和荟萃分析结果表明，目前尚无证据表明IVF/ICSI患者在卵泡早期应用rLH会受益。
Objectives To investigate the effect of recombinant human luteinizing hormone supplementation (rLH priming) during the early follicular phase on invitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.Methods In order to evaluate available evidence regarding the efficacy of rLH priming in IVF/ICSI procedures, a systematic review and meta-analysis was preformed. Searches were conducted on MEDLINE (R), EMBASE and the Cochrane Database of Clinical Trials without language limitation, but were restricted to randomized controlled trials (RCTs).Results Three RCTs including 346 patients were included in this meta-analysis, which demonstrated that rLH priming did not increase ongoing pregnancy rate. Although less recombinant follicle-stimulating hormone (rFSH) was required and the oestradiol level was higher on the day of human chorionic gonadotropin administration in the rLH priming group, the numbers of oocytes retrieved and embryos produced were comparable between patients treated with rLH priming and those treated with rFSH alone.Conclusions This systematic review and meta-analysis has demonstrated that at present there is insufficient evidence that patients undergoing IVF/ICSI may benefit from rLH priming during the early follicular phase.