High-intensity focused ultrasound: past, present, and future in neurosurgery
High-intensity focused ultrasound: past, present, and future in neurosurgery
复制标题
高强度聚焦超声：神经外科的过去、现在和未来
DOI：
10.3171/2017.11.focus17610
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发表时间：
2018-02-01
影响因子：
4.1
通讯作者：
Fiani, Brian
中科院分区：
文献类型：
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作者：
Quadri, Syed A.;Waqas, Muhammad;Fiani, Brian
自从林恩和他的同事在1942年首次描述了使用聚焦超声(FUS)波进行颅内消融以来，使用这项新技术在治疗几种脑部疾病方面取得了很大进展。在现代微创时代，高强度聚焦超声(HIFU)有望用于多种神经外科应用，包括治疗肿瘤、中风、癫痫和功能性疾病。尽管HIFU作为一种潜在的治疗手段在大脑中的使用已经进行了几十年的研究，但相对较少的神经科学家、神经学家，甚至神经外科医生对其熟悉。在这篇广泛的综述中，作者打算阐明HIFU目前在不同神经外科途径中的使用及其作用机制，并提供各种试验的最新结果和预期在不久的将来各种临床前研究的进展。虽然最初的技术挑战已经克服，技术也得到了改进，但到目前为止只进行了很少的临床试验。未来几年，与神经疾病相关的临床试验数量预计将增加，因为这种新的治疗设备似乎具有巨大的扩展潜力。HIFU在不同的内科和外科学科中用于治疗不同的病理有很大的机会。随着这项技术获得认可，它将为进一步的研究机会和创新打开大门。
Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it. In this extensive review, the authors intend to shed light on the current use of HIFU in different neurosurgical avenues and its mechanism of action, as well as provide an update on the outcome of various trials and advances expected from various preclinical studies in the near future. Although the initial technical challenges have been overcome and the technology has been improved, only very few clinical trials have thus far been carried out. The number of clinical trials related to neurological disorders is expected to increase in the coming years, as this novel therapeutic device appears to have a substantial expansive potential. There is great opportunity to expand the use of HIFU across various medical and surgical disciplines for the treatment of different pathologies. As this technology gains recognition, it will open the door for further research opportunities and innovation.