Rhodium-catalyzed synthesis of substituted isoquinolonesviaa selective decarbonylation/alkyne insertion cascade of phthalimides
Rhodium-catalyzed synthesis of substituted isoquinolonesviaa selective decarbonylation/alkyne insertion cascade of phthalimides
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通过邻苯二甲酰亚胺的选择性脱羰/炔插入级联，铑催化合成取代的异喹诺酮
DOI：
10.1039/d0ob01793k
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发表时间：
2020
影响因子：
3.2
通讯作者：
Shen Li-Jing
中科院分区：
文献类型：
--
作者：
Xu Fen;Zhu Wen-Jing;Wang Juan;Ma Qi;Shen Li-Jing
建立了铑催化的邻苯二甲酰亚胺脱甲基化/炔插入级联反应体系。该反应可以以操作简单的方式进行，并提供了以中等到良好的产率获得一系列异喹诺酮类药物的便利途径。该反应通过连续的脱羰化/炔烃插入/分子内环化反应进行，具有良好的官能团耐受性、充足的底物范围以及一锅即可构建C-C和C-N键。
A rhodium-catalyzed decarbonylation/alkyne insertion cascade of phthalimides has been established. The reaction can be carried out in an operationally simple manner and provides expedient access to a series of isoquinolones in moderate to good yields. This reaction proceeded through a sequential decarbonylation/alkyne insertion/intramolecular annulation procedure and featured good functional group tolerance, ample substrate scope, and the construction of C–C and C–N bonds in one pot.