Dietary polyamine intake and polyamines measured in urine.
Dietary polyamine intake and polyamines measured in urine.
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膳食多胺摄入量和尿液中测量的多胺。
DOI：
10.1080/01635581.2014.949801
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Thompson,PatriciaA
中科院分区：
文献类型：
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作者：
Vargas,AshleyJ;Ashbeck,ErinL;Thomson,CynthiaA;Gerner,EugeneW;Thompson,PatriciaA
最近，饮食中的多胺已被证实与结直肠癌前恶性病变的风险增加有关。由于多胺是在细胞中合成并从饮食中摄取的，因此开发一种暴露的生物标志物是具有挑战性的。过量的多胺主要通过尿液排出。本初步研究旨在确定尿多胺排泄的饮食相关性作为假定的暴露生物标志物。通过食物频率问卷（FFQ）评估36名男性24小时尿液样本中膳食多胺/其他营养素与尿中乙酰化多胺水平的相关性。多胺与尿n8 -乙酰亚精胺呈高度正相关（相关系数r = 0.37，P= 0.03），但调整总能量摄入后相关性减弱（r = 0.07，P= 0.68）。膳食能量摄入本身与尿乙酰化多胺总输出呈正相关（r = 0.40，P= 0.02）。在能量调整分析中，叶酸和食物中的叶酸与尿中N1、n12 -二乙酰精胺相关（r = 0.34，P= 0.05和r = - 0.39，P= 0.02）。红肉与尿乙酰化多胺总量呈负相关（r = - 0.42，P= 0.01）。我们的研究结果表明，能量、叶酸、叶酸、饱和脂肪和红肉的摄入量，而不是ffq估计的饮食多胺，与尿多胺相关。
Dietary polyamines have recently been associated with increased risk of pre-malignant colorectal lesions. Because polyamines are synthesized in cells and taken up from dietary sources, development of a biomarker of exposure is challenging. Excess polyamines are primarily excreted in the urine. This pilot study seeks to identify dietary correlates of excreted urinary polyamines as putative biomarkers of exposure. Dietary polyamines/other nutrients were estimated from a food frequency questionnaire (FFQ) and correlated with urinary levels of acetylated polyamines in 36 men using 24-h urine samples. Polyamines, abundant in cheese and citrus, were highly positively correlated with urinary N8-acetylspermidine (correlation coefficient; r = 0.37,P= 0.03), but this correlation was attenuated after adjustment for total energy intake (r = 0.07,P= 0.68). Dietary energy intake itself was positively correlated with urinary total acetylated polyamine output (r = .40,P= 0.02). In energy-adjusted analyses, folic acid and folate from food were associated with urinary N1,N12-diacetylspermine (r = 0.34,P= 0.05 and r = −0.39,P= 0.02, respectively). Red meat negatively correlated with total urinary acetylated polyamines (r = −0.42,P= 0.01). Our findings suggest that energy, folate, folic acid, saturated fat, and red meat intake, as opposed to FFQ-estimated dietary polyamines, are correlated with urinary polyamines.