Objective sleep duration and timing predicts completion of in vitro fertilization cycle.
Objective sleep duration and timing predicts completion of in vitro fertilization cycle.
复制标题
客观睡眠持续时间和时间可预测体外受精周期的完成。
DOI：
10.1007/s10815-021-02260-8
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发表时间：
2021
影响因子：
3.1
通讯作者：
Dunietz,GalitLevi
中科院分区：
文献类型：
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作者：
Pimolsri,Chawanont;Lyu,Xiru;Goldstein,Cathy;Fortin,ChelseaN;Mumford,SunniL;Smith,YolandaR;Lanham,MichaelS;O'Brien,LouiseM;Dunietz,GalitLevi
目的检查客观测量的睡眠持续时间和睡眠时间与完成体外受精 (IVF) 周期的几率之间的关联。方法这项前瞻性队列研究招募了 2015 年至 2017 年间在一家大型三级医疗中心接受 IVF 的 48 名女性。在 IVF 周期开始前 1-2 周，通过腕戴式体动记录仪评估睡眠情况。生殖和体外受精周期数据以及人口和健康信息是从医疗图表中获得的。使用逻辑回归模型检查睡眠持续时间、中点和就寝时间与 IVF 周期完成的关系，并根据年龄和抗苗勒氏管激素水平进行调整。一项子分析排除了非白班工作的女性，以控制昼夜节律失调。结果所有参与者的中位年龄为 33 岁，其中 29% 的女性>35 岁。十名女性在胚胎移植前取消了体外受精周期。与完成周期的女性相比，这些女性的睡眠时间较短、夜间醒来较多、睡眠效率较低且睡眠时间较晚。较长的睡眠时间与未完成 IVF 周期的几率较低相关（OR = 0.88；95% CI 0.78, 1.00，睡眠时间每增加 20 分钟）。与中点较早和就寝时间较早的女性相比，睡眠中点较晚和就寝时间较晚的女性未完成周期的几率更高；或 = 1.24； 95%CI 1.09、1.40 和 OR = 1.33；对于 20 分钟增量，95%CI 分别为 1.17、1.53。这些结果与年龄、抗苗勒氏管激素水平或睡眠持续时间无关，并且在排除轮班工作女性后仍然显着。结论较短的睡眠持续时间和较晚的睡眠时间会增加胚胎移植前未完成周期的几率。
PurposeTo examine associations between objectively measured sleep duration and sleep timing with odds of completion of an in vitro fertilization (IVF) cycle.MethodsThis prospective cohort study enrolled 48 women undergoing IVF at a large tertiary medical center between 2015 and 2017. Sleep was assessed by wrist-worn actigraphy, 1–2 weeks prior to initiation of the IVF cycle. Reproductive and IVF cycle data and demographic and health information were obtained from medical charts. Sleep duration, midpoint, and bedtime were examined in relation to IVF cycle completion using logistic regression models, adjusted for age and anti-Müllerian hormone levels. A sub-analysis excluded women who worked non-day shifts to control for circadian misalignment.ResultsThe median age of all participants was 33 years, with 29% of women >35 years. Ten women had an IVF cycle cancelation prior to embryo transfer. These women had shorter sleep duration, more nocturnal awakenings, lower sleep efficiency, and later sleep timing relative to those who completed their cycle. Longer sleep duration was associated with lower odds of uncompleted IVF cycle (OR = 0.88; 95%CI 0.78, 1.00, per 20-min increment of increased sleep duration). Women with later sleep midpoint and later bedtime had higher odds of uncompleted cycle relative to those with earlier midpoint and earlier bedtime; OR = 1.24; 95%CI 1.09, 1.40 and OR = 1.33; 95%CI 1.17, 1.53 respectively, for 20-min increments. These results were independent of age, anti-Müllerian hormone levels, or sleep duration, and remained significant after exclusion of shift-working women.ConclusionsShorter sleep duration and later sleep timing increase the odds of uncompleted cycles prior to embryo transfer.