Clinicopathological characteristics and prognosis of poorly cohesive cell subtype of gastric cancer
Clinicopathological characteristics and prognosis of poorly cohesive cell subtype of gastric cancer
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DOI：
10.1007/s10147-021-02069-6
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发表时间：
2022-01-27
影响因子：
3.3
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Nakamura, Kenichi;Eto, Kojiro;Baba, Hideo
背景世界卫生组织（WHO）新的胃癌分类包括一个组织学亚型，即粘附性差的胃癌（PCC），其中包括印戒细胞（SRC）表型。我们的目的是根据2010年WHO组织学亚型检查术前临床和术后组织学诊断之间的一致性，并比较这些亚型的诊断。方法研究队列包括2005年至2019年接受胃切除术的665例患者。组织学亚型分为PCC-NOS（非印戒细胞亚型）、SRC和非PCC，其根据2010年WHO胃癌分类由主要成分定义。分析临床与病理诊断的一致性，比较三种亚型的临床病理特征和生存结局。结果非PCC型443例（66.7%），PCC-NOS型112例（16.8%），SRC型110例（16.5%）。性别、年龄、肿瘤部位、大小、大体类型、病理TNM分期差异均有显著性（均P
Background The new World Health Organization (WHO) classification of gastric cancer includes a histological subtype of poorly cohesive carcinoma (PCC), which includes signet-ring cell (SRC) phenotype. We aimed to examine the concordance between preoperative clinical and postoperative histological diagnoses according to the 2010 WHO histological subtypes and to compare the prognoses of these subtypes. Methods The study cohort comprised 665 patients who underwent gastrectomy from 2005 to 2019. Histological subtypes were classified into PCC-NOS (non-signet ring cell subtype), SRC, and non-PCC, which were defined by the predominant component in accordance with the 2010 WHO classification of gastric cancer. The concordance of clinical and pathological diagnosis was examined and clinicopathological characteristics and survival outcome of the three subtypes compared. Results The cancers of 443 patients (66.7%) were classified as non-PCC, of 112 patients (16.8%) as PCC-NOS, and of 110 patients (16.5%) as SRC predominant subtypes. Significant differences in sex, age, tumor location, size, macroscopic type, and pathological TNM category (all P