Atheromatous plaque cap thickness can be determined by quantitative color analysis during angioscopy: implications for identifying the vulnerable plaque.
Atheromatous plaque cap thickness can be determined by quantitative color analysis during angioscopy: implications for identifying the vulnerable plaque.
复制标题
动脉粥样硬化斑块帽厚度可以通过血管镜检查期间的定量颜色分析来确定：对识别易损斑块的影响。
DOI：
10.1002/clc.4960270104
复制
发表时间：
2004
影响因子：
2.7
通讯作者：
Abela2nd,GeorgeS
中科院分区：
文献类型：
--
作者：
Miyamoto,Akira;Prieto,AlejandroR;Friedl,StephanE;Lin,FreemanC;Muller,JamesE;Nesto,RichardW;Abela2nd,GeorgeS
Background:Coronary angioscopy in acute myocardial infarction has frequently revealed disrupted yellow lesions. Furthermore, postmortem studies have demonstrated that these lesions have thin collagenous caps with underlying lipid‐rich cores.Hypothesis:We hypothesized that the yellow color is due to visualization of reflected light from the lipid‐rich yellow core through a thin fibrous cap. Thus, quantification of yellow color saturation may estimate plaque cap thickness and identify vulnerable plaques.Methods:To test this hypothesis, the feasibility of detecting cap thickness was tested using both a model of lipid‐rich plaque and human atherosclerotic plaque. The model was constructed by injecting a yellow beta‐carotene‐lipid emulsion subendothelially into normal bovine aorta. Human plaque was obtained from cadaver aorta. Digitized images were obtained by angioscopy, and percent yellow saturation was analyzed using a custom computer program. Plaque cap thickness was measured by planimetry of digitized images on stained tissue sections. Percent yellow saturation was then correlated with plaque cap thickness.Results:In the bovine model, plaque cap thickness and percent yellow saturation correlated inversely (r2= 0.91; p = 0.0001). In human plaques, yellow saturation was significantly greater in atheromatous than in white plaques (p< 0.0004). Also, there was a high correlation between plaque cap thickness and yellow saturation at various angles of view between 40° and 90°, the greatestbetween50° and 80° (r2= 0.75 to 0.88).Conclusion:Plaque cap thickness is a determinant of plaque color, and this can be assessed by quantitative colorimetry. Thus, plaque color by angioscopy may be useful for detecting vulnerable plaques.
