Noradrenergic induction of odor-specific neural habituation and olfactory memories.
Noradrenergic induction of odor-specific neural habituation and olfactory memories.
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DOI：
10.1523/jneurosci.3853-08.2008
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发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Mooney R
中科院分区：
文献类型：
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作者：
Shea SD;Katz LC;Mooney R
对于许多哺乳动物来说，个体识别同种依赖于嗅觉线索。人们认为，当同种气味线索与强烈激发的社交事件引发的去甲肾上腺素（NA）激增同时发生时，某些个人识别记忆就会被储存起来。这种熟悉的刺激引起减少的行为反应，变化可能与NA依赖的可塑性在嗅球（OB）。除了在这些行为记忆中的作用外，OB中的NA信号似乎也与更任意气味的辨别有关。尽管如此，没有NA门控机制的长期可塑性在OB已被直接观察到在体内。在这里，我们报告说，NA从蓝斑（LC）的释放，当耦合到气味介绍，在主嗅球（MOB）的局部行为，导致一个特定的长期抑制配对气味的反应。这些影响在食物气味和尿液（一种重要的社会识别线索）中都有观察到。此外，在随后的行为测试中，小鼠表现出习惯成对的尿液刺激，这表明这种LC介导的嗅觉神经可塑性，诱导麻醉下，可以存储一个单独的识别记忆，是可观察到的恢复。
For many mammals, individual recognition of conspecifics relies on olfactory cues. Certain individual recognition memories are thought to be stored when conspecific odor cues coincide with surges of noradrenaline (NA) triggered by intensely arousing social events. Such familiar stimuli elicit reduced behavioral responses, a change likely related to NA-dependent plasticity in the olfactory bulb (OB). In addition to its role in these ethological memories, NA signaling in the OB appears to be relevant for the discrimination of more arbitrary odorants as well. Nonetheless, no NA-gated mechanism of long-term plasticity in the OB has ever been directly observed in vivo. Here we report that NA release from locus coeruleus (LC), when coupled to odor presentation, acts locally in the main olfactory bulb (MOB) to cause a specific long-lasting suppression of respones to paired odors. These effects were observed for both food odors and urine, an important social recognition cue. Moreover, in subsequent behavioral tests, mice exhibited habituation to paired urine stimuli, suggesting that this LC-mediated olfactory neural plasticity, induced under anesthesia, can store an individual recognition memory that is observable upon recovery.