Lipid metabolism and exercise
Lipid metabolism and exercise
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DOI：
10.7600/jpfsm.2.149
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
T. Hashimoto
中科院分区：
文献类型：
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作者：
T. Hashimoto
脂肪细胞中脂解的调节涉及许多脂滴（LD）相关蛋白如围脂蛋白、激素敏感脂肪酶（HSL）、脂肪甘油三酯脂肪酶（ATGL）及其激活蛋白CGI-58的协调作用。最近，作者和我的同事描述了在活性脂解过程中出现在细胞质中的微LD（mLD）的细胞起源和生理意义，以及关键脂解蛋白在分化的3 T3-L1脂肪细胞中对mLD的作用。我们认为，除了预先存在的中央LD的表面，LD相关蛋白，如perilipin，CGI-58，HSL和ATGL积极参与脂肪分解的mLD形成FA再酯化，但可能致力于增加总三酰甘油（TAG）营业额，从而潜在的净FA释放。因此，调节mLD以及LD相关蛋白可能是针对脂质相关代谢疾病的有吸引力的治疗靶点。旨在通过脂肪细胞中的活性脂解（即脂肪动员）和肌肉中的脂肪酸（FA）氧化（即脂肪利用）来减少脂肪的生理策略如运动训练已成为针对代谢紊乱的优选治疗剂。然而，对于运动训练诱导的主动脂肪分解能力增强的分子机制知之甚少，未来应予以阐明。
The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated proteins such as perilipin, hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and its activator protein, CGI-58. Recently, the author and my colleagues described the cellular origin and physiological significance of micro LDs (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key liplolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. We suggested that, besides the surface of preexisting central LDs, LD-associated proteins such as perilipin, CGI-58, HSL, and ATGL are actively involved in lipolysis on mLDs that are formed by FA re-esterification but probably devote to increasing total triacylglycerol (TAG) turnover and thus potentially net FA release. Thus, regulation of mLDs as well as LD-associated proteins may be an attractive therapeutic target against lipid-associated metabolic diseases. Physiological strategies such as exercise training aimed toward fat loss by active lipolysis in adipocytes (i.e. fat mobilization) and fatty acid (FA) oxidation in muscles (i.e. fat utilization) have become of preferred therapeutic agents against metabolic disorders. However, yet remarkably little is known about molecular mechanisms underlying augmented capacity of active lipolysis induced by exercise training, which should be elucidated in the future.